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BAGE3
BAGE3 (BAGE family member 3, B melanoma antigen 3) is a member of the BAGE family, also known by the alias CT2.3. UniProt describes it as a candidate gene encoding tumour antigens, and its molecular function has not yet been established. Browse Assay Genie's current range of BAGE3 research reagents below, or read on for the biology behind the target.
BAGE3 is a human protein whose function is listed as unknown in UniProt. The entry describes the gene only as a candidate gene encoding tumour antigens, so no enzymatic activity, receptor interaction or signalling mechanism has been assigned to it. Researchers working with BAGE3 should therefore treat it as an under-characterised member of its family rather than a protein with a defined pathway role.
The BAGE3 protein belongs to the BAGE family, the gene group recognised by HGNC under the identifier HGNC:15728. UniProt annotates the protein as secreted, and the NCBI Gene summary, provided by the Alliance of Genome Resources, similarly states that it is predicted to be located in the extracellular region. No enzyme classification applies. The BAGE3 gene is recorded at 21p11.2, in a region that is not represented on the reference assembly, which is worth bearing in mind when designing sequence-based work. No mouse or rat ortholog is defined in the data used for this page.
The official name, BAGE family member 3, replaced the earlier designation B melanoma antigen family, member 3. UniProt uses the protein name B melanoma antigen 3, and CT2.3 is a recorded alias. These names reflect the way the family was first identified as a source of tumour antigens. Beyond this naming and the candidate tumour antigen annotation, the available sources do not describe tissue expression, disease associations or binding partners, so those details are not given here.
BAGE3 is annotated as a candidate gene encoding tumour antigens, making it a subject of interest for studies of antigens associated with melanoma.
As a member of the BAGE family, BAGE3 can be studied alongside related family genes to compare their features and annotation.
UniProt lists BAGE3 as secreted and NCBI reports a predicted extracellular location, which frames questions about where the protein acts.
With its function still listed as unknown, BAGE3 is a candidate for work aimed at characterising the role of poorly annotated proteins.
The function of BAGE3 is listed as unknown in UniProt, which describes it only as a candidate gene encoding tumour antigens. NCBI Gene adds that the protein is predicted to be located in the extracellular region, consistent with the UniProt annotation of it as secreted.
The HGNC-approved name is BAGE family member 3, and UniProt calls the protein B melanoma antigen 3. The alias CT2.3 is recorded, and the previous name was B melanoma antigen family, member 3. Check the datasheet of any product for its validated reactivity.
No mouse or rat ortholog is defined in the data supplied for BAGE3, so conservation cannot be stated from these sources. The protein belongs to the BAGE family, and its gene lies at 21p11.2 in a region not on the reference assembly.
Other BAGE family members and tumour antigen targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q86Y29; product specifications from Assay Genie datasheets.
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