GPR132
GPR132 (G protein-coupled receptor 132, also known as G2A) is a seven-pass transmembrane receptor of the GPCR superfamily. It may act as a sensor of oxidised free fatty acids and of acidic pH, and it is linked to cell-cycle control and apoptosis. Browse Assay Genie's current range of GPR132 research reagents below, or read on for the biology behind the target.
GPR132 belongs to the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. These seven-pass transmembrane proteins respond to extracellular cues and activate intracellular signal transduction pathways. UniProt annotates GPR132 as a possible receptor for oxidised free fatty acids derived from linoleic and arachidonic acids, such as 9-hydroxyoctadecadienoic acid (9-HODE). It is thought to activate a G alpha protein, most likely G alpha(q).
Functional annotation links GPR132 to cell-cycle regulation and cell fate. It functions at the G2/M checkpoint to delay mitosis and may be involved in apoptosis. It may also act as a sensor of oxidative state, mediating cellular responses such as the secretion of paracrine signals and attenuation of proliferation. In addition, it may have proton-sensing activity, mediating accumulation of intracellular inositol phosphates at acidic pH.
The human GPR132 gene encodes a protein of the G protein-coupled receptor 1 family, classed by HGNC among the Class A orphans, and the receptor localises to the cell membrane. Alternative splicing produces multiple transcript variants. GPR132 was originally reported to be a receptor for lysophosphatidylcholine, but a later study (PubMed 15653487) retracted this finding and instead suggested that the protein is an effector of lysophosphatidylcholine action. The mouse ortholog is Gpr132, and the receptor is also known by the alias G2A.
GPR132 is a Class A orphan whose ligands remain uncertain, making it a subject for studies of oxidised fatty acid and lysophospholipid signalling.
GPR132 functions at the G2/M checkpoint to delay mitosis, so it is relevant to studies of how cells control entry into division.
GPR132 may sense oxidative state and mediate responses such as paracrine signal secretion and reduced proliferation.
GPR132 may mediate intracellular inositol phosphate accumulation at acidic pH, supporting work on proton-sensing receptors.
GPR132 is a membrane GPCR that may be a receptor for oxidised free fatty acids such as 9-HODE and is thought to activate G alpha(q). It acts at the G2/M checkpoint to delay mitosis, may be involved in apoptosis, and may sense oxidative state and acidic pH.
Yes. G2A is an alias for GPR132, the HGNC-approved symbol for G protein-coupled receptor 132. The UniProt entry names it probable G protein-coupled receptor 132. Alternative splicing of the gene gives multiple transcript variants, so literature may refer to either name.
It was first reported as a lysophosphatidylcholine receptor, but a later study (PubMed 15653487) retracted that finding and suggested GPR132 is instead an effector of lysophosphatidylcholine action. Current annotation favours oxidised free fatty acids and protons as possible activating cues. The mouse ortholog is Gpr132.
Other G protein-coupled receptors, including orphan and proton-sensing family members, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UNW8; product specifications from Assay Genie datasheets.