MARCKSL1
MARCKSL1 (MARCKS like 1, also known as MARCKS-related protein, F52, MacMARCKS, MLP1 and MLP) is a member of the MARCKS family that controls cell movement by regulating actin cytoskeleton homeostasis. It also contributes to protein kinase C and calmodulin signalling. Browse Assay Genie's current range of MARCKSL1 research reagents below, or read on for the biology behind the target.
MARCKSL1 controls cell movement by regulating actin cytoskeleton homeostasis and the formation of filopodia and lamellipodia. Its activity depends on its phosphorylation state. When unphosphorylated, MARCKSL1 induces cell migration. When phosphorylated by MAPK8, it induces the formation and stabilisation of actin bundles, which reduces actin plasticity and restricts cell movement, including neuronal migration. MARCKSL1 may also be involved in coupling the protein kinase C and calmodulin signal transduction systems.
The MARCKSL1 gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family, whose members play roles in cytoskeletal regulation, protein kinase C signalling and calmodulin signalling. The MARCKSL1 protein is found in the cytoplasm, associated with the cytoskeleton, and at the cell membrane. According to the NCBI Gene summary, it also affects the formation of adherens junctions. Alternative splicing of the MARCKSL1 gene results in multiple transcript variants, and pseudogenes are located on the long arm of chromosomes 6 and 10.
The protein has been described under several names, including MARCKS-like protein, MARCKS-related protein, F52, MacMARCKS, MLP1 and MLP. Mouse and rat orthologs are both designated Marcksl1, which allows the biology of MARCKSL1 to be studied in common rodent models.
Unphosphorylated MARCKSL1 induces cell migration, making it a relevant target for studies of how cells control movement.
MARCKSL1 regulates actin homeostasis and filopodium and lamellipodium formation, and phosphorylation by MAPK8 stabilises actin bundles.
Phosphorylation of MARCKSL1 by MAPK8 restricts cell movement, including neuronal migration, linking the protein to neuronal positioning.
MARCKSL1 may couple protein kinase C and calmodulin signal transduction systems, and it also affects adherens junction formation.
MARCKSL1 regulates actin cytoskeleton homeostasis and the formation of filopodia and lamellipodia, thereby controlling cell movement. Unphosphorylated, it promotes migration. Phosphorylated by MAPK8, it stabilises actin bundles and restricts movement, including neuronal migration. It may also couple protein kinase C and calmodulin signalling.
MARCKSL1 is also called MARCKS-related protein, F52, MacMARCKS, MLP1 and MLP. Its HGNC full name is MARCKS like 1, and a previous name was MARCKS-like protein. Alternative splicing of the gene gives multiple transcript variants. Check the datasheet of any product for its validated reactivity.
Yes. Mouse and rat both carry an ortholog named Marcksl1. The protein belongs to the MARCKS family, whose members share roles in cytoskeletal regulation, protein kinase C signalling and calmodulin signalling. Check the datasheet of any product for its validated reactivity.
Other MARCKS family members, actin-regulating proteins and kinase signalling partners with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P49006; product specifications from Assay Genie datasheets.