ODC1
ODC1 (ornithine decarboxylase 1, also known as ODC) is the enzyme that catalyses the first and rate-limiting step of polyamine biosynthesis, converting ornithine into putrescine. Putrescine is the precursor of the polyamines spermidine and spermine. Browse Assay Genie's current range of ODC1 research reagents below, or read on for the biology behind the target.
ODC1 catalyses the conversion of ornithine to putrescine, the first and rate-limiting step in the polyamine biosynthesis pathway. Putrescine is the precursor for the polyamines spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes ranging from DNA replication to apoptosis, which places the ODC1 protein at a control point for cell growth.
The enzyme belongs to the Orn/Lys/Arg decarboxylase class-II family and is classified as EC 4.1.1.17. Its activity level varies in response to growth-promoting stimuli, and it shows a high turnover rate compared with other mammalian proteins. The HGNC places the ODC1 gene in the groups of decarboxylases and small nucleolar RNA protein coding host genes. Mouse and rat each have an orthologous Odc1 gene.
The gene was originally localised to both chromosomes 2 and 7, but has since been determined to lie on 2p25, with a pseudogene on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. The enzyme is also referred to as ornithine decarboxylase, or ODC, in the literature.
ODC1 performs the rate-limiting step that converts ornithine to putrescine, making it a central point for studying spermidine and spermine biosynthesis.
Polyamines are essential for cell proliferation, and ODC1 activity changes in response to growth-promoting stimuli, so it is a useful readout of growth signalling.
Polyamines are implicated in processes from DNA replication to apoptosis, linking ODC1 to the study of these fundamental cellular events.
ODC1 has a high turnover rate compared with other mammalian proteins, making it a model for studying rapid regulation of enzyme levels.
ODC1 catalyses the first and rate-limiting step of polyamine biosynthesis, converting ornithine into putrescine. Putrescine is the precursor of spermidine and spermine, polyamines that are essential for cell proliferation and implicated in processes from DNA replication to apoptosis.
ODC1 is the HGNC symbol for ornithine decarboxylase 1, and the enzyme is also called ODC or ornithine decarboxylase. NCBI Gene reports multiple alternatively spliced transcript variants that encode distinct isoforms, and a pseudogene is located on 7q31-qter.
Mouse and rat both have an orthologous gene, Odc1, so the enzyme can be studied in common rodent models. The protein belongs to the Orn/Lys/Arg decarboxylase class-II family. Check the datasheet of any product for its validated reactivity.
Other polyamine pathway enzymes, decarboxylases and cell proliferation markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P11926; product specifications from Assay Genie datasheets.