SCG5
SCG5 (secretogranin V), also known as 7B2, SgV and SGNE1, is a secreted neuroendocrine protein that acts as a molecular chaperone. It is best known for controlling the activation of the prohormone convertase PCSK2 (PC2) in the regulated secretory pathway. Browse Assay Genie's current range of SCG5 research reagents below, or read on for the biology behind the target.
SCG5 is a chaperone for the prohormone convertase PCSK2 (PC2). It binds inactive PCSK2 in the endoplasmic reticulum and prevents premature activation in the regulated secretory pathway. It then helps transport PCSK2 to later compartments of the pathway, where PCSK2 is proteolytically matured and activated. SCG5 is also required for cleavage of PCSK2, but it does not appear to be involved in PCSK2 folding. The C-terminal peptide of SCG5 inhibits PCSK2 in vitro.
Beyond PCSK2, SCG5 plays a role in regulating pituitary hormone secretion. It can also prevent aggregation of islet amyloid polypeptide (IAPP). The NCBI Gene summary describes the protein as a secreted chaperone that prevents aggregation of other secreted proteins, including proteins associated with neurodegenerative and metabolic disease. Phosphorylation of the protein has been shown to inhibit its chaperone function. The SCG5 gene belongs to the 7B2 family, and the human protein is the product of a gene on chromosome 15.
The gene was previously named secretory granule, neuroendocrine protein 1 (7B2 protein), which explains the aliases 7B2 and SGNE1. HGNC classes it in the granin gene group, hence the name secretogranin V (SgV). The SCG5 locus also produces an ARHGAP11A-SCG5 readthrough transcript and the corresponding ARHGAP11A-SCG5 protein. Mouse and rat both carry a Scg5 ortholog, so SCG5 can be studied in common rodent models of neuroendocrine function.
SCG5 controls the transport and activation of PCSK2 in the regulated secretory pathway, making it central to studies of prohormone convertase biology.
SCG5 plays a role in regulating pituitary hormone secretion, so it is relevant to neuroendocrine and secretory pathway research.
SCG5 prevents aggregation of secreted proteins, including IAPP, linking it to work on amyloid formation and chaperone activity.
The secreted chaperone function of SCG5 touches proteins associated with neurodegenerative and metabolic disease, supporting mechanistic studies in both areas.
SCG5 is a secreted molecular chaperone for PCSK2 (PC2). It binds inactive PCSK2 in the endoplasmic reticulum, prevents premature activation, and aids transport to later secretory compartments where PCSK2 is matured. It also helps regulate pituitary hormone secretion and prevents IAPP aggregation.
SCG5 is also called secretogranin V, 7B2, SgV and SGNE1. UniProt lists the protein as neuroendocrine protein 7B2, and an earlier gene name was secretory granule, neuroendocrine protein 1 (7B2 protein). HGNC places it in the granin gene group.
Yes. Mouse and rat each have an ortholog named Scg5, so rodent models can be used to study its function. The SCG5 gene also yields an ARHGAP11A-SCG5 readthrough transcript. Check the datasheet of any product for its validated reactivity.
Other secretogranins and secretory pathway proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P05408; product specifications from Assay Genie datasheets.