CD86
CD86 (CD86 molecule, also known as B7-2, B7.2 and CD28LG2) is a type I membrane protein of the immunoglobulin superfamily, expressed by antigen-presenting cells. It is a ligand for CD28 and CTLA-4 on T cells and shapes the direction of T-cell activation. Browse Assay Genie's current range of CD86 research reagents below, or read on for the biology behind the target.
CD86 is a cell-surface ligand expressed by antigen-presenting cells. It engages two proteins on the surface of T cells: CD28 antigen and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). The outcome depends on the partner. Binding of CD86 to CD28 provides a costimulatory signal for T-cell activation. Binding to CTLA-4 negatively regulates T-cell activation and diminishes the immune response. This dual role makes CD86 a central point of control in the balance between immune activation and restraint.
The CD86 gene encodes a type I membrane protein that belongs to the immunoglobulin superfamily. HGNC places it among the CD molecules, the V-set domain containing genes and the B7 family. Alternative splicing of the gene produces several transcript variants that encode different isoforms. The protein is found at the cell membrane, and the mouse counterpart is Cd86. Researchers who work with the CD86 protein, or who use a CD86 antibody or CD86 ELISA kit, are usually studying costimulation and antigen presentation.
The protein is known by several names: B7-2, B7.2 and CD28LG2, the last reflecting its role as a ligand for CD28. An earlier HGNC name was CD86 antigen (CD28 antigen ligand 2, B7-2 antigen). Outside its immunological role, UniProt also records that, in the context of microbial infection, CD86 acts as a receptor for adenovirus subgroup B.
CD86 binding to CD28 provides a costimulatory signal for T-cell activation, making it a key ligand for studying how T cells are primed.
Binding of CD86 to CTLA-4 negatively regulates T-cell activation and diminishes the immune response, linking it to checkpoint biology.
CD86 is expressed by antigen-presenting cells, so it is widely used to characterise how these cells engage T cells.
UniProt records CD86 as a receptor for adenovirus subgroup B, which gives it relevance in microbial infection research.
CD86 is a ligand on antigen-presenting cells for CD28 and CTLA-4 on T cells. Binding to CD28 gives a costimulatory signal that promotes T-cell activation, while binding to CTLA-4 negatively regulates activation and diminishes the immune response.
CD86 is also called B7-2, B7.2 and CD28LG2. Its earlier HGNC name was CD86 antigen (CD28 antigen ligand 2, B7-2 antigen). Alternative splicing gives several transcript variants that encode different isoforms of the protein.
A mouse ortholog, Cd86, is recorded in the data. Check the datasheet of any product for its validated reactivity. UniProt also notes that CD86 acts as a receptor for adenovirus subgroup B during microbial infection.
Other CD molecules, immune cell markers and immunoglobulin superfamily members with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P42081; product specifications from Assay Genie datasheets.