TAF13
TAF13 (TATA-box binding protein associated factor 13, also known as TAFII18 or TAF2K) is a small nuclear subunit of the TFIID basal transcription factor complex. It contributes to promoter binding and the initiation of RNA polymerase II-dependent transcription. Browse Assay Genie's current range of TAF13 research reagents below, or read on for the biology behind the target.
TAF13 is a component of TFIID, the basal transcription factor complex that plays a major role in initiating RNA polymerase II (Pol II)-dependent transcription. TFIID recognises and binds promoters through its TATA-box-binding subunit, TBP, and promotes assembly of the pre-initiation complex. The complex consists of TBP and TBP-associated factors (TAFs), including TAF1 to TAF13. Within this assembly, TAF13, together with TAF11 and TBP, plays a key role during promoter binding by the TFIID and TFIIA transcription factor complexes.
The TAF13 gene encodes a small subunit that is associated with a subset of TFIID complexes. The protein interacts with TBP and with two other small TFIID subunits, TAF10 and TAF11. It is localised to the nucleus and belongs to the TAF13 family. HGNC places it in the group of general transcription factor IID complex subunits. A pseudogene is located on chromosome 6, and the mouse ortholog is Taf13.
Initiation of transcription by Pol II requires the activities of more than 70 polypeptides. TFIID coordinates these activities: it binds the core promoter to position the polymerase, acts as a scaffold for assembly of the remaining transcription machinery and serves as a channel for regulatory signals. TAFs may take part in basal transcription, act as coactivators, contribute to promoter recognition or modify general transcription factors to aid complex assembly. The TAF13 protein was previously named TBP-associated factor, RNA polymerase II, K, 18kD, which explains the aliases TAFII18 and TAF2K.
TAF13 is a TFIID subunit involved in the initiation of RNA polymerase II-dependent transcription and pre-initiation complex assembly.
TAF13, with TAF11 and TBP, plays key roles in promoter binding by the TFIID and TFIIA complexes.
TAF13 interacts with TBP, TAF10 and TAF11, making it relevant to studies of how small TFIID subunits assemble.
As a member of the general transcription factor IID complex subunits group, TAF13 informs work on basal transcription machinery and coactivator function.
TAF13 is a subunit of TFIID, the basal transcription factor complex that helps initiate RNA polymerase II-dependent transcription. Together with TAF11 and TBP, it plays key roles during promoter binding by the TFIID and TFIIA complexes. It is found in the nucleus.
TAF13 is also called TAFII18 and TAF2K. Earlier names include TBP-associated factor, RNA polymerase II, K, 18kD, and the UniProt name is transcription initiation factor TFIID subunit 13. These names all refer to the same TFIID subunit.
According to the NCBI Gene summary, TAF13 interacts with TBP and with two other small TFIID subunits, TAF10 and TAF11. It is associated with a subset of TFIID complexes. A mouse ortholog, Taf13, exists; check the datasheet of any product for its validated reactivity.
Other TAF family members and TFIID-associated transcription factors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q15543; product specifications from Assay Genie datasheets.