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GPS2
GPS2 (G protein pathway suppressor 2) is a protein involved in G protein-MAPK signalling cascades and an integral subunit of the NCOR1-HDAC3 corepressor complex. Its name reflects its ability to suppress RAS- and MAPK-mediated signals when overexpressed. Browse Assay Genie's current range of GPS2 research reagents below, or read on for the biology behind the target.
GPS2 is a signalling repressor. The NCBI Gene summary describes it as a protein involved in G protein-mitogen-activated protein kinase (MAPK) signalling cascades. When overexpressed in mammalian cells, the GPS2 gene product can potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, which suggests that its function is signal repression.
GPS2 is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and HGNC places the gene in the group of NCoR/SMRT transcriptional repression complex subunits. Work on this complex showed that it inhibits JNK activation through the GPS2 subunit. This could provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. UniProt records the protein in the nucleus, the mitochondrion and the cytosol.
GPS2 also has a role in microbial infection. UniProt annotates it as required for efficient replication of hepatitis C virus (HCV), where it promotes the interaction between VAPA and the HCV protein NS5A. The mouse ortholog is designated Gps2, so the protein can be studied in both human and mouse systems.
GPS2 is an integral subunit of the NCOR1-HDAC3 complex, making it relevant to studies of NCoR/SMRT-mediated transcriptional repression.
GPS2 suppresses RAS- and MAPK-mediated signals and interferes with JNK activity, so it is studied in signal repression.
The NCOR1-HDAC3 complex inhibits JNK activation through GPS2, a possible mechanism for hormone-mediated antagonism of AP1 function.
GPS2 promotes the interaction between VAPA and HCV NS5A, and is required for efficient HCV replication.
GPS2 represses signalling. When overexpressed it suppresses RAS- and MAPK-mediated signals and interferes with JNK activity. It is also an integral subunit of the NCOR1-HDAC3 complex, which inhibits JNK activation through this subunit. In HCV infection it promotes the VAPA-NS5A interaction.
The HGNC-approved name is G protein pathway suppressor 2, and no other aliases or previous symbols are listed. According to UniProt, the protein localises to the nucleus, the mitochondrion and the cytosol. The gene is listed under NCoR/SMRT transcriptional repression complex subunits.
The mouse ortholog is Gps2, so mouse models can be used to study it. A disease-related role is documented in viral infection: UniProt reports that GPS2 is required for efficient hepatitis C virus replication. Check the datasheet of any product for its validated reactivity.
Other NCoR/SMRT complex components, MAPK and JNK pathway proteins and HCV-related host factors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q13227; product specifications from Assay Genie datasheets.
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