SEMA3E
SEMA3E (semaphorin 3E) is a secreted class 3 semaphorin that signals through the cell surface receptor PLXND1. It regulates cytoskeletal dynamics, angiogenesis and synapse specificity, and is also known as M-SemaK, KIAA0331, coll-5 and SEMAH. Browse Assay Genie's current range of SEMA3E research reagents below, or read on for the biology behind the target.
SEMA3E plays an important role in signalling via the cell surface receptor PLXND1. Through this pathway it mediates reorganisation of the actin cytoskeleton, leading to the retraction of cell projections. It promotes focal adhesion disassembly and inhibits the adhesion of endothelial cells to the extracellular matrix. SEMA3E regulates angiogenesis both during embryogenesis and after birth, can down-regulate sprouting angiogenesis, and is required for normal vascular patterning in the embryo. It also plays an important role in ensuring the specificity of synapse formation.
Semaphorins are a large family of conserved secreted and membrane-associated proteins that carry a semaphorin (Sema) domain and a PSI domain, found in plexins, semaphorins and integrins, in the N-terminal extracellular region. Based on sequence and structural similarities they are placed in eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3 to 7. SEMA3E is a class 3 member, and the semaphorin family as a whole serve as axon guidance ligands via multimeric receptor complexes, some if not all of which contain plexin proteins. HGNC places the SEMA3E gene in the groups of immunoglobulin like domain containing proteins and semaphorins. Multiple transcript variants encoding different isoforms have been reported for this gene, and the mouse ortholog is Sema3e.
The protein is also recorded as Semaphorin-3E, and its earlier HGNC name was sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E. Alternative names include M-SemaK, KIAA0331, coll-5 and SEMAH. These aliases are worth searching when comparing older literature on semaphorin signalling in the vasculature and nervous system.
SEMA3E regulates angiogenesis during embryogenesis and after birth, and can down-regulate sprouting angiogenesis, making it a focus for studies of vessel growth.
SEMA3E is required for normal vascular patterning during embryogenesis, so it is used to study how guidance cues organise developing vessels.
SEMA3E helps ensure the specificity of synapse formation, linking this semaphorin to research on neural circuit wiring.
SEMA3E signalling drives actin reorganisation, retraction of cell projections and focal adhesion disassembly, relevant to cell adhesion and motility studies.
SEMA3E is a secreted ligand that signals via the cell surface receptor PLXND1. It reorganises the actin cytoskeleton, retracts cell projections, promotes focal adhesion disassembly and inhibits endothelial cell adhesion to the extracellular matrix. It also regulates angiogenesis and supports specific synapse formation.
SEMA3E is also known as semaphorin 3E, Semaphorin-3E, M-SemaK, KIAA0331, coll-5 and SEMAH. Its earlier HGNC name was sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E. Multiple transcript variants encoding different isoforms have been described for the gene.
Semaphorins are a large family of conserved secreted and membrane-associated proteins, and vertebrates contain classes 3 to 7. SEMA3E is a class 3 member, and the mouse ortholog is Sema3e. Check the datasheet of any product for its validated reactivity.
Other class 3 semaphorins and members of the wider semaphorin family involved in axon guidance and vascular signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O15041; product specifications from Assay Genie datasheets.