PLPPR1
PLPPR1 (phospholipid phosphatase related 1, also known as PRG-3 or LPPR1) is a member of the plasticity-related gene family expressed in the brain. It may play a role in neurite outgrowth and neurogenesis. Browse Assay Genie's current range of PLPPR1 research reagents below, or read on for the biology behind the target.
PLPPR1 is a neuronal protein that may play a role in neurite outgrowth and neurogenesis. It localises to the cell membrane and to neuron projections. The PLPPR1 gene encodes a member of the plasticity-related gene (PRG) family, whose members mediate lipid phosphate phosphatase activity in neurons and are known to be involved in neuronal plasticity. Unlike what its family relationships might suggest, the PLPPR1 protein does not perform its function through enzymatic phospholipid degradation.
The protein belongs to the PA-phosphatase related phosphoesterase family, and HGNC places the gene in the phospholipid phosphatase related group. The PLPPR1 gene is strongly expressed in brain and shows dynamic expression regulation during brain development and neuronal excitation. Alternatively spliced transcript variants have been observed, and all of them encode the same protein. Orthologous genes are present in mouse and rat (both Plppr1).
The gene is also known by the aliases PRG-3, LPPR1, MGC26189 and FLJ20300. The PRG-3 name reflects its membership of the plasticity-related gene family, and the phospholipid phosphatase related nomenclature reflects its relationship to lipid phosphate phosphatases. Researchers studying PLPPR1 often work with it alongside other family members such as PLPPR4, to compare how related proteins contribute to neuronal function.
PLPPR1 may play a role in neurite outgrowth, making it a candidate for work on how neurons extend and shape their projections.
The protein may contribute to neurogenesis, so it is relevant to studies of how new neurons form in the developing brain.
As a plasticity-related gene family member, PLPPR1 is of interest for understanding the molecular basis of neuronal plasticity.
PLPPR1 expression is dynamically regulated during brain development and neuronal excitation, supporting its use in studies of regulated gene expression in the brain.
PLPPR1 may play a role in neurite outgrowth and neurogenesis. It is a member of the plasticity-related gene family, which is involved in neuronal plasticity. Despite its relationship to lipid phosphate phosphatases, PLPPR1 does not act through enzymatic phospholipid degradation.
PLPPR1 stands for phospholipid phosphatase related 1. It is also called PRG-3 (plasticity-related gene 3), LPPR1, MGC26189 and FLJ20300. UniProt lists the protein as phospholipid phosphatase-related protein type 1. Alternative splicing produces transcript variants that encode the same protein.
PLPPR1 has orthologues in mouse and rat, both named Plppr1. The gene is strongly expressed in brain, with dynamic regulation during brain development and neuronal excitation. Check the datasheet of any product for its validated reactivity.
Other phospholipid phosphatase related proteins and plasticity-related gene family members with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8TBJ4; product specifications from Assay Genie datasheets.