KRT10
KRT10 (keratin 10, also known as K10, CK10 and KPP) is a type I (acidic) cytokeratin and a member of the intermediate filament family. It contributes to the cytoskeleton of epithelial cells and has been shown to bind a surface protein of Streptococcus pneumoniae. Browse Assay Genie's current range of KRT10 research reagents below, or read on for the biology behind the target.
KRT10 is a structural protein of the intermediate filament (IF) superfamily. Keratins are heteropolymeric proteins, meaning that the filaments they form are assembled from more than one keratin type. Together with actin microfilaments and microtubules, these intermediate filaments make up the cytoskeleton of epithelial cells. KRT10 belongs to the type I, or acidic, cytokeratins.
UniProt records the KRT10 protein in the cytoplasm, at the cell surface and in the extracellular space. A surface role is described in microbial infection: KRT10 binds the S. pneumoniae protein PsrP and mediates adherence of the bacteria to lung cell lines. Reducing KRT10 levels decreases adherence, while overexpression increases it. Neither protein needs to be glycosylated for this interaction to occur.
The KRT10 gene sits within a cluster of keratin family members on chromosome 17q21, and HGNC classifies it in the type I keratin group. Mutations in the gene are associated with epidermolytic hyperkeratosis. Earlier names for the gene include keratosis palmaris et plantaris and keratin 10, type I, which explain the alias KPP. Mouse and rat each have a Krt10 ortholog, so the protein can be studied in common rodent models.
KRT10 is a type I cytokeratin that forms intermediate filaments, which, with actin and microtubules, make up the cytoskeleton of epithelial cells.
Mutations in the KRT10 gene are associated with epidermolytic hyperkeratosis, making the protein a focus for studies of this keratin-related condition.
KRT10 binds S. pneumoniae PsrP and mediates bacterial adherence to lung cell lines, which makes it relevant to host-pathogen interaction research.
KRT10 lies in a cluster of keratin genes on chromosome 17q21, so it is often studied alongside other keratin family members.
KRT10 is a type I cytokeratin that assembles with other keratins into intermediate filaments, part of the epithelial cytoskeleton. UniProt also reports that it binds S. pneumoniae PsrP and mediates bacterial adherence to lung cell lines.
KRT10 is the HGNC symbol for keratin 10. Aliases are K10, CK10 and KPP. Previous names are keratosis palmaris et plantaris and keratin 10, type I. UniProt lists the protein as keratin, type I cytoskeletal 10.
Mouse and rat both carry a Krt10 ortholog. In humans, mutations in the gene are associated with epidermolytic hyperkeratosis. Check the datasheet of any product for its validated reactivity before choosing a reagent for a given species.
Other keratins and intermediate filament proteins of the epithelial cytoskeleton, including members of the type I keratin group.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P13645; product specifications from Assay Genie datasheets.