FOXN2
FOXN2, also known as HTLF and formerly named human T-cell leukaemia virus enhancer factor, is a nuclear forkhead domain protein. It binds the purine-rich region of the HTLV-I long terminal repeat and may contribute to transcriptional regulation of that element. Browse Assay Genie's current range of FOXN2 research reagents below, or read on for the biology behind the target.
FOXN2 (forkhead box N2) is a forkhead domain binding protein that localises to the nucleus. The UniProt annotation describes its function as binding to the purine-rich region in the HTLV-I LTR, the long terminal repeat of the human T-cell leukaemia virus type I. On that basis, the NCBI Gene summary indicates that FOXN2 may function in the transcriptional regulation of the viral long terminal repeat.
The FOXN2 gene belongs to the HGNC gene group of forkhead boxes, the family of proteins defined by a forkhead DNA-binding domain. The human FOXN2 protein is catalogued in UniProt as Forkhead box protein N2. Within the same family, FOXN1 and FOXN4 are other members of the FOXN subgroup.
The name HTLF reflects the early characterisation of the protein as the human T-cell leukaemia virus enhancer factor. That historical name, and the symbol derived from it, still appear in older literature, so it is worth searching under both HTLF and FOXN2 when reviewing the field. Researchers studying FOXN2 are generally interested in its role as a DNA-binding regulator of transcription and in its interaction with viral regulatory sequences.
FOXN2 is a forkhead domain protein that may regulate transcription, making it a subject for studies of forkhead factor function.
FOXN2 binds the purine-rich region of the HTLV-I long terminal repeat, linking it to research on viral promoter control.
As a member of the forkhead box gene group, FOXN2 supports comparative work across FOX transcription factors.
FOXN2 is a nuclear DNA-binding protein, relevant to studies of how sequence-specific factors engage regulatory elements.
FOXN2 is a forkhead domain binding protein found in the nucleus. UniProt reports that it binds the purine-rich region in the HTLV-I LTR, and the NCBI Gene summary suggests it may function in transcriptional regulation of the human T-cell leukaemia virus long terminal repeat.
FOXN2 stands for forkhead box N2. The alias HTLF comes from its former name, human T-cell leukaemia virus enhancer factor. UniProt lists the protein as Forkhead box protein N2. Searching under all of these names helps when reviewing older literature.
FOXN2 belongs to the HGNC gene group of forkhead boxes, which are defined by a forkhead DNA-binding domain. FOXN1 and FOXN4 are related FOXN members. Check the datasheet of any product for its validated reactivity.
Other forkhead box N family transcription factors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P32314; product specifications from Assay Genie datasheets.