PSG2
PSG2 (pregnancy specific beta-1-glycoprotein 2, also known as PSGGB, PSG1, CEA and PSBG2) is a secreted glycoprotein of the pregnancy-specific glycoprotein family. Like other PSGs, it is made by placental trophoblasts and released into the maternal circulation during pregnancy. Browse Assay Genie's current range of PSG2 research reagents below, or read on for the biology behind the target.
PSG2 belongs to the human pregnancy-specific glycoproteins (PSGs), a family of proteins synthesised in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. The PSG2 protein is annotated as secreted. No specific function for PSG2 is described in the sources used here, so its role is best considered in the context of the wider PSG family.
Molecular cloning and analysis of several PSG genes has shown that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Members of the CEA family have a single N domain, structurally similar to immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. HGNC classifies the PSG2 gene within the V-set domain containing group and the pregnancy specific glycoproteins group. Most PSGs carry an arg-gly-asp (RGD) motif in the N-terminal domain, which has been shown to act as an adhesion recognition signal for several integrins.
The PSG2 gene has accumulated several aliases, including PSGGB, PSG1, CEA and PSBG2. Because PSG1 and CEA are also names of other genes, it is worth checking the gene symbol and UniProt accession when searching the literature. Other PSG genes, such as PSG1, PSG3, PSG6 and PSG11, belong to the same family and are often studied alongside PSG2.
PSGs are synthesised in large amounts by placental trophoblasts, making PSG2 relevant to studies of trophoblast products.
PSG proteins are released into the maternal circulation during pregnancy, which makes PSG2 a candidate for work on secreted pregnancy-associated proteins.
PSG2 sits within the CEA subgroup of the immunoglobulin superfamily, supporting comparative studies of domain organisation across the family.
Most PSGs carry an N-terminal RGD motif, an adhesion recognition signal for several integrins, relevant to studies of PSG interactions.
No specific function for PSG2 is given in the sources used here. It is a secreted member of the pregnancy-specific glycoprotein family, which is made by placental trophoblasts and released into the maternal circulation during pregnancy. Most PSGs have an RGD motif that can act as an integrin adhesion signal.
PSG2 is also known as pregnancy-specific beta-1-glycoprotein 2, PSGGB, PSG1, CEA and PSBG2. Some of these aliases overlap with other genes, so the HGNC symbol, NCBI Gene ID and UniProt accession are the most reliable identifiers when comparing PSG2 data.
The PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family within the immunoglobulin superfamily. CEA family members have a single N domain similar to an immunoglobulin variable domain, followed by a variable number of constant-like A and/or B domains.
Other pregnancy-specific glycoproteins from the same CEA-family subgroup.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P11465; product specifications from Assay Genie datasheets.