SLC31A1
SLC31A1 (solute carrier family 31 member 1) is a high-affinity copper transporter found in the cell membrane, also known as hCTR1, CTR1 and COPT1. It functions as a homotrimer to effect the uptake of dietary copper. Browse Assay Genie's current range of SLC31A1 research reagents below, or read on for the biology behind the target.
SLC31A1 is a high-affinity copper transporter found in the cell membrane. According to the NCBI Gene summary, the encoded protein functions as a homotrimer to effect the uptake of dietary copper. UniProt also annotates a role within the endosomal compartment: the protein mobilises copper(1+) out of endosomes, making copper(1+) available for export out of the cell. Together these activities place SLC31A1 at the centre of cellular copper handling, from entry at the plasma membrane to movement through the endocytic pathway.
The protein is annotated in UniProt as High affinity copper uptake protein 1 and belongs to the copper transporter (Ctr) family, SLC31A subfamily. Its recorded subcellular locations include the cell membrane, apical and basolateral cell membrane, and the early, late and recycling endosome membranes. The mouse and rat orthologs are both named Slc31a1, which is useful when planning work across model systems. Researchers studying the SLC31A1 gene or the SLC31A1 protein will often consider both surface and endosomal pools.
The gene sits in HGNC's solute carrier family 31 group. Its previous HGNC name was solute carrier family 31 (copper transporter), member 1, and it is also known as hCTR1, CTR1 and COPT1. These aliases appear throughout the literature on copper transport, so searches under any of them may be relevant when reviewing SLC31A1 biology.
SLC31A1 effects the uptake of dietary copper as a high-affinity transporter, making it a central protein for studying how cells acquire copper.
SLC31A1 mobilises copper(1+) out of the endosomal compartment, so it is relevant to how copper moves through endocytic membranes.
As a homotrimeric member of the Ctr family and SLC31A subfamily, SLC31A1 is a model for studying solute carrier assembly and function.
SLC31A1 is annotated at apical and basolateral cell membranes as well as endosomes, supporting studies of transporter distribution within cells.
SLC31A1 is a high-affinity copper transporter that functions as a homotrimer to effect the uptake of dietary copper. UniProt also describes it mobilising copper(1+) out of the endosomal compartment, making it available for export out of the cell.
SLC31A1 is also called hCTR1, CTR1 and COPT1. Its UniProt protein name is High affinity copper uptake protein 1, and its earlier HGNC name was solute carrier family 31 (copper transporter), member 1.
Yes. Mouse and rat both have an ortholog named Slc31a1. This allows copper transport to be studied in rodent models, but check the datasheet of any product for its validated reactivity.
Other solute carrier family members and membrane transporters with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O15431; product specifications from Assay Genie datasheets.