SHB
SHB is an SH2 domain-containing adaptor protein that links activated receptors to downstream signalling components. Also known as SH2 domain-containing adapter protein B, it has been implicated in angiogenesis, T-cell receptor signalling and apoptosis. Browse Assay Genie's current range of SHB research reagents below, or read on for the biology behind the target.
SHB is an adaptor protein that regulates several signal transduction cascades by linking activated receptors to downstream signalling components. Adaptors of this kind have no enzymatic activity of their own. They organise signalling complexes at the receptor. NCBI Gene annotates the SHB protein as enabling phosphotyrosine residue binding, consistent with the role of its SH2 domain in recognising phosphorylated receptors.
UniProt describes a possible role for SHB in angiogenesis through regulation of FGFR1, VEGFR2 and PDGFR signalling. It may also contribute to T-cell antigen receptor (TCR) signalling, interleukin-2 signalling, apoptosis and neuronal cell differentiation, where it is thought to mediate basic-FGF and NGF-induced signalling cascades. In insulin-producing cells, SHB may regulate IRS1 and IRS2 signalling.
The SHB gene encodes a cytoplasmic protein that is also found at the cell membrane, and NCBI Gene reports it in the cytosol. Predicted involvement includes haematopoietic stem cell proliferation, negative regulation of oocyte maturation and positive regulation of immune response. HGNC places SHB in the SH2 domain containing gene group. Earlier names include SHB adaptor protein (a Src homology 2 protein) and Src homology 2 domain containing adaptor protein B. The mouse ortholog is Shb.
SHB may regulate FGFR1, VEGFR2 and PDGFR signalling, making it a point of interest in studies of blood vessel formation.
SHB may act in T-cell antigen receptor and interleukin-2 signalling, and is predicted to promote immune response.
SHB may regulate IRS1 and IRS2 signalling in insulin-producing cells, linking adaptor function to insulin pathways.
SHB may mediate basic-FGF and NGF-induced cascades involved in neuronal cell differentiation, and may also contribute to apoptosis.
SHB is an adaptor protein that links activated receptors to downstream signalling components. UniProt reports a possible role in angiogenesis via FGFR1, VEGFR2 and PDGFR, and in TCR signalling, interleukin-2 signalling, apoptosis and neuronal differentiation. It may also regulate IRS1 and IRS2 signalling in insulin-producing cells.
No aliases are listed, but HGNC records previous names including SHB adaptor protein (a Src homology 2 protein) and Src homology 2 domain containing adaptor protein B. UniProt names the protein SH2 domain-containing adapter protein B. HGNC places it in the SH2 domain containing gene group.
A mouse ortholog, Shb, is recorded for the human gene. Researchers working in mouse models should consider this correspondence, though cross-species behaviour should be confirmed experimentally. Check the datasheet of any product for its validated reactivity.
Other targets at Assay Genie that may be of interest alongside SHB in signalling research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q15464; product specifications from Assay Genie datasheets.