EMILIN2
EMILIN2 (elastin microfibril interfacer 2, also known as EMILIN-2, FOAP-10 and FLJ33200) is a secreted extracellular matrix protein associated with elastic fibres. It is thought to anchor smooth muscle cells to elastic fibres and has cell adhesive capacity. Browse Assay Genie's current range of EMILIN2 research reagents below, or read on for the biology behind the target.
EMILIN2 is an extracellular matrix glycoprotein that may be responsible for anchoring smooth muscle cells to elastic fibres. It may be involved not only in the formation of the elastic fibre but also in the processes that regulate vessel assembly. The protein also has cell adhesive capacity, which fits a role at the interface between cells and the elastic matrix. NCBI Gene predicts that it enables an extracellular matrix constituent conferring elasticity.
The EMILIN2 gene encodes a protein of the EMI domain containing and C1q domain containing gene groups, as classified by HGNC. UniProt records the product, EMILIN-2, as secreted into the extracellular space and extracellular matrix, consistent with NCBI Gene placing it in the extracellular region. Researchers searching for an EMILIN2 antibody, EMILIN2 ELISA kit or recombinant EMILIN2 protein are generally studying matrix biology and vascular tissue. The mouse ortholog is Emilin2.
Beyond its structural role, NCBI Gene lists EMILIN2 as involved in several processes, including positive regulation of angiogenesis, positive regulation of defense response to bacterium and positive regulation of platelet aggregation. The protein is named for its relationship to elastin microfibrils, and it is a close relative of EMILIN1 within the same gene groups. Aliases such as FOAP-10 and FLJ33200 may appear in older literature and databases.
EMILIN2 may contribute to elastic fibre formation and is predicted to be an extracellular matrix constituent conferring elasticity.
The protein may anchor smooth muscle cells to elastic fibres and may help regulate vessel assembly.
NCBI Gene lists EMILIN2 as involved in positive regulation of angiogenesis, making it relevant to studies of vessel growth.
EMILIN2 has cell adhesive capacity and is annotated as involved in positive regulation of platelet aggregation.
EMILIN2 is a secreted extracellular matrix protein that may anchor smooth muscle cells to elastic fibres. It may contribute to elastic fibre formation and to the regulation of vessel assembly, and it has cell adhesive capacity. NCBI Gene also links it to positive regulation of angiogenesis.
The HGNC name is elastin microfibril interfacer 2. UniProt calls the protein EMILIN-2, and other aliases include FOAP-10 and FLJ33200. HGNC lists no previous names. Using all of these terms helps when searching older papers and databases.
A mouse ortholog, Emilin2, is recorded. In humans, EMILIN2 belongs to the EMI domain containing and C1q domain containing gene groups, and EMILIN1 is a related family member. Check the datasheet of any product for its validated reactivity.
EMILIN1, a related elastin microfibril interfacer, and other extracellular matrix targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BXX0; product specifications from Assay Genie datasheets.