TM4SF1
TM4SF1 (transmembrane 4 L six family member 1, also known as L6 and M3S1) is a cell-surface member of the L6 tetraspanin family. It takes part in signal transduction events that influence cell development, activation, growth and motility. Browse Assay Genie's current range of TM4SF1 research reagents below, or read on for the biology behind the target.
TM4SF1 belongs to the transmembrane 4 superfamily, also called the tetraspanin family. Most members of this superfamily are cell-surface proteins defined by four hydrophobic domains. According to the NCBI Gene summary, these proteins mediate signal transduction events that play a role in regulating cell development, activation, growth and motility. TM4SF1 is placed specifically in the L6 tetraspanin family.
The TM4SF1 protein is a cell surface antigen and is highly expressed in different carcinomas. This pattern has made it a recurring subject in cancer biology, where researchers study how surface tetraspanins relate to tumour cell behaviour. UniProt lists the protein as a membrane protein, consistent with its role at the cell surface. The mouse ortholog is Tm4sf1, which allows comparative work in murine models.
The TM4SF1 gene is catalogued by HGNC as a member of the transmembrane 4 L six family. The approved name, transmembrane 4 L six family member 1, replaced the earlier name transmembrane 4 superfamily member 1. The aliases L6 and M3S1 are still found in the literature, so searches for TM4SF1 antibody, TM4SF1 protein or L6 antigen work often need to take all of these names into account.
TM4SF1 is a cell surface antigen that is highly expressed in different carcinomas, making it a point of interest in tumour studies.
As a tetraspanin, TM4SF1 is linked to signal transduction events that regulate cell growth, activation and development.
Members of this family mediate signalling involved in cell motility, which makes TM4SF1 relevant to studies of how cells move.
TM4SF1 is described as a cell surface antigen, so it is used as a membrane marker when profiling carcinoma cells.
TM4SF1 is a cell-surface tetraspanin. According to the NCBI Gene summary, proteins of this superfamily mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TM4SF1 is also a cell surface antigen that is highly expressed in different carcinomas.
The approved name is transmembrane 4 L six family member 1. Aliases include L6 and M3S1, and the previous name was transmembrane 4 superfamily member 1. UniProt names the protein Transmembrane 4 L6 family member 1, so all of these terms may appear in publications.
A mouse ortholog, Tm4sf1, is recorded for the human gene. TM4SF1 sits in the L6 tetraspanin family, and its high expression in different carcinomas is a notable disease association. Check the datasheet of any product for its validated reactivity.
Another TM4SF family member and related transmembrane proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P30408; product specifications from Assay Genie datasheets.