WNT6
WNT6 (Wnt family member 6, previously wingless-type MMTV integration site family, member 6) is a secreted signalling protein of the Wnt family. It acts as a ligand for frizzled receptors and is a probable developmental protein. Browse Assay Genie's current range of WNT6 research reagents below, or read on for the biology behind the target.
WNT6 is a ligand for members of the frizzled family of seven transmembrane receptors. It is considered a probable developmental protein and may be a signalling molecule that affects the development of discrete regions of tissues. WNT6 is likely to signal over only a few cell diameters, which points to a local, short-range mode of action. The protein is secreted and found in the extracellular space and extracellular matrix.
The WNT6 gene belongs to the WNT gene family, a group of structurally related genes that encode secreted signalling proteins. Members of this family have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. The human WNT6 protein is 97% identical at the amino acid level to mouse Wnt6, which makes the mouse a close comparative system. The gene lies in the chromosome 2q35 region, where it is clustered with WNT10A.
WNT6 has been linked to cancer biology in several contexts. It is overexpressed in a cervical cancer cell line and is strongly coexpressed with WNT10A in a colorectal cancer cell line, and this overexpression may play key roles in carcinogenesis. Together with CAV1, WNT6 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through activation of the canonical Wnt receptor signalling pathway. Studies of WNT6 therefore sit at the intersection of developmental signalling and tumour biology.
WNT6 is a probable developmental protein that may affect the development of discrete regions of tissues, making it relevant to patterning studies.
As a ligand for frizzled receptors, WNT6 is used to study canonical Wnt receptor signalling and short-range ligand action.
WNT6 is overexpressed in a cervical cancer cell line and coexpressed with WNT10A in colorectal cancer cells.
With CAV1, WNT6 may promote resistance of gastric cancer cells to anthracycline drugs via canonical Wnt signalling.
WNT6 is a secreted ligand for frizzled family seven transmembrane receptors. It is a probable developmental protein that may affect the development of discrete tissue regions, and it is likely to signal over only a few cell diameters. It can also activate canonical Wnt signalling in gastric cancer cells.
The HGNC approved name is Wnt family member 6, and UniProt lists the protein as Protein Wnt-6. The previous name was wingless-type MMTV integration site family, member 6. No alternative gene symbols are recorded. The gene belongs to the Wnt family.
Human WNT6 is 97% identical to the mouse Wnt6 protein at the amino acid level, so mouse studies are informative for the human protein. Check the datasheet of any product for its validated reactivity. The human gene is clustered with WNT10A at 2q35.
Other Wnt family ligands, including WNT10A, which is clustered with WNT6 on chromosome 2q35.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y6F9; product specifications from Assay Genie datasheets.