EFEMP1
EFEMP1 (EGF-like fibulin extracellular matrix protein 1, also known as FBLN3 or S1-5) is a secreted extracellular matrix glycoprotein of the fibulin family. It binds EGFR and may influence cell adhesion, migration and differentiation. Browse Assay Genie's current range of EFEMP1 research reagents below, or read on for the biology behind the target.
EFEMP1 is a secreted protein found in the extracellular space and extracellular matrix. It binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and activation of downstream signalling pathways. It may also play a role in cell adhesion and migration, and may act as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.
The EFEMP1 gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all family members, the EFEMP1 protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminal fibulin-type domain. Alternatively spliced transcript variants have been described, and they encode the same protein. Mouse and rat orthologues are both named Efemp1.
The gene is upregulated in malignant gliomas and may contribute to the aggressive nature of these tumours. Mutations in EFEMP1 are associated with Doyne honeycomb retinal dystrophy. Previous names and aliases include fibrillin-like, FBLN3, S1-5, MTLV, DHRD and FBNL, reflecting its EGF-like repeat structure and its place among the fibulins. These features make EFEMP1 a useful target for work on matrix biology, EGFR signalling and tumour biology, whether you use an EFEMP1 antibody, an EFEMP1 ELISA kit or recombinant EFEMP1 protein.
EFEMP1 is a fibulin-family matrix glycoprotein with tandem EGF-like repeats and a C-terminal fibulin-type domain, making it a model for matrix protein studies.
EFEMP1 binds EGFR and induces its autophosphorylation, activating downstream signalling pathways, so it is relevant to ligand-receptor research.
EFEMP1 is upregulated in malignant gliomas and may contribute to the aggressive nature of these tumours.
Mutations in EFEMP1 are associated with Doyne honeycomb retinal dystrophy, linking the protein to inherited retinal disease.
EFEMP1 is a secreted extracellular matrix protein that binds EGFR, inducing its autophosphorylation and downstream signalling. It may also play a role in cell adhesion and migration, may negatively regulate chondrocyte differentiation, and may regulate glial cell behaviour in the olfactory epithelium.
EFEMP1 is also known as FBLN3 (fibulin-3), S1-5, MTLV, DHRD and FBNL. Earlier names include fibrillin-like and EGF-containing fibulin-like extracellular matrix protein 1. Alternatively spliced transcript variants have been described, and they encode the same protein.
Yes. Mutations in the EFEMP1 gene are associated with Doyne honeycomb retinal dystrophy, and the gene is upregulated in malignant gliomas, where it may contribute to their aggressive nature. Mouse and rat Efemp1 orthologues exist; check the datasheet of any product for its validated reactivity.
Related fibulin-family and EGF-containing extracellular matrix proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q12805; product specifications from Assay Genie datasheets.