A1BG
A1BG (alpha-1-B glycoprotein) is a secreted plasma glycoprotein whose function remains unknown. Its sequence resembles the variable regions of certain members of the immunoglobulin supergene family, and it is the founding entry in the HGNC gene nomenclature list. Browse Assay Genie's current range of A1BG research reagents below, or read on for the biology behind the target.
A1BG is a glycoprotein found in plasma. According to the NCBI Gene summary, the protein encoded by this gene is of unknown function, and no catalytic activity, receptor role or binding partner is described in the sources used for this page. Researchers studying A1BG therefore generally approach it as a plasma protein to be detected, quantified and characterised rather than as a pathway component with an established mechanism.
The A1BG protein is annotated as secreted. Its sequence shows similarity to the variable regions of some members of the immunoglobulin supergene family, and HGNC places the gene in the group of immunoglobulin like domain containing genes. This relationship to immunoglobulin-type domains is the main structural clue to its biology. The human A1BG gene has orthologues in the mouse and rat, both named A1bg, which allows comparative work across species.
The HGNC symbol A1BG corresponds to the approved name alpha-1-B glycoprotein, and UniProt lists the protein as Alpha-1B-glycoprotein. No alternative symbols or previous names are recorded. Because the function is not defined, A1BG antibody, A1BG ELISA kit and A1BG protein reagents are typically used to measure the protein in biological fluids and to help establish where and when it is present.
A1BG is a plasma glycoprotein of unknown function, making its detection and quantification a starting point for understanding its biology.
Sequence similarity to immunoglobulin variable regions makes A1BG a point of comparison within the immunoglobulin-like domain gene group.
As a secreted glycoprotein, A1BG is relevant to researchers examining the properties and behaviour of proteins circulating in plasma.
Mouse and rat A1bg orthologues allow the human gene and protein to be examined alongside related rodent counterparts.
The function of A1BG is unknown. NCBI Gene describes the encoded protein as a plasma glycoprotein of unknown function, and UniProt provides no functional annotation. What is known is that it is secreted and resembles the variable regions of some immunoglobulin supergene family proteins.
The HGNC-approved name is alpha-1-B glycoprotein, with the symbol A1BG, and UniProt calls the protein Alpha-1B-glycoprotein. No aliases or previous symbols are recorded in the data used here, so searches generally use A1BG or the full name.
Yes, orthologues named A1bg are listed for both mouse and rat. Cross-species reactivity varies between reagents, so check the datasheet of any product for its validated reactivity.
Other plasma glycoproteins and immunoglobulin-like domain proteins that researchers often study alongside A1BG.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P04217; product specifications from Assay Genie datasheets.