CHAD
CHAD (chondroadherin, also known as SLRR4A) is a secreted cartilage matrix protein of the small leucine-rich proteoglycan family. It promotes the attachment of chondrocytes, fibroblasts and osteoblasts and may help regulate chondrocyte growth and proliferation. Browse Assay Genie's current range of CHAD research reagents below, or read on for the biology behind the target.
CHAD is a cartilage matrix protein that mediates cell adhesion. It promotes the attachment of chondrocytes, fibroblasts and osteoblasts, and for chondrocytes and fibroblasts at least, this binding is mediated by the integrin alpha(2)beta(1). It may also play an important role in regulating chondrocyte growth and proliferation. RefSeq describes it as a protein thought to mediate adhesion of isolated chondrocytes.
The CHAD gene encodes chondroadherin, which is secreted into the extracellular space and deposited in the extracellular matrix. The protein contains 11 leucine-rich repeats flanked by cysteine-rich regions. Chondroadherin messenger RNA is present in chondrocytes at all ages. Mouse and rat both carry a Chad ortholog, so the CHAD protein can be studied in common rodent models of cartilage biology.
CHAD belongs to the small leucine-rich proteoglycan (SLRP) family and is placed in SLRP class IV. HGNC lists it in the small leucine rich repeat proteoglycans gene group under the symbol CHAD, with SLRR4A as an alias. Researchers studying cartilage matrix organisation, cell-matrix adhesion and integrin-mediated signalling in connective tissue cells use CHAD as a defined target, whether they measure it with a CHAD antibody or a CHAD ELISA kit.
CHAD is a cartilage matrix protein, making it a relevant target for studying how the extracellular matrix of cartilage is organised.
CHAD is thought to mediate adhesion of isolated chondrocytes, and promotes attachment of fibroblasts and osteoblasts as well.
Attachment of chondrocytes and fibroblasts to CHAD is mediated by integrin alpha(2)beta(1), linking the protein to cell-matrix interactions.
CHAD may play an important role in regulating chondrocyte growth and proliferation, a question of interest in cartilage research.
CHAD promotes the attachment of chondrocytes, fibroblasts and osteoblasts. For chondrocytes and fibroblasts, at least, this is mediated by integrin alpha(2)beta(1). It may also regulate chondrocyte growth and proliferation. It is a secreted protein of the extracellular matrix.
CHAD is the HGNC symbol for chondroadherin, and SLRR4A is a listed alias. The name reflects its role in chondrocyte adhesion. The protein belongs to the small leucine-rich proteoglycan family, class IV subfamily.
Yes. Both mouse and rat have an orthologous gene named Chad. Chondroadherin messenger RNA is present in chondrocytes at all ages. Check the datasheet of any product for its validated reactivity.
Integrin subunits, other small leucine-rich proteoglycans and cartilage matrix proteins relevant to CHAD research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O15335; product specifications from Assay Genie datasheets.