CFHR2
CFHR2 (complement factor H related 2, also known as FHR2, HFL3 and CFHL2) is a secreted Sushi domain-containing protein involved in complement regulation. It belongs to the complement factor H-related family and can compete with the physiological inhibitor CFH. Browse Assay Genie's current range of CFHR2 research reagents below, or read on for the biology behind the target.
CFHR2 is involved in complement regulation. Its dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH (complement factor H). Through this competition, the CFHR2 protein is positioned as a modulator of how complement activity is controlled at tissue surfaces. UniProt also records that it can associate with lipoproteins and may play a role in lipid metabolism, suggesting a link between complement biology and lipid handling.
The CFHR2 gene is one member of the complement factor H-related (CFHR) gene family. These genes are clustered together with the complement factor H gene on chromosome 1 and are all involved in regulation of complement. HGNC places the protein in the Sushi domain containing group and in the complement system regulators and receptors group. The protein is secreted. Alternatively spliced transcript variants have been reported for the gene.
CFHR2 has appeared in the literature under several names, including FHR2, HFL3 and CFHL2. The previous HGNC names were H factor (complement)-like 3 and complement factor H-related 2. Mutations in CFHR genes as a family have been associated with dense deposit disease and atypical haemolytic-uraemic syndrome, which is why this group of proteins is of interest to researchers studying complement-mediated kidney disease. CFHR1 is another member of the same gene cluster.
CFHR2 is involved in complement regulation and competes with CFH, making it relevant to work on how complement control is balanced.
Mutations in CFHR genes have been associated with dense deposit disease and atypical haemolytic-uraemic syndrome.
CFHR2 can associate with lipoproteins and may play a role in lipid metabolism, connecting complement and lipid research.
Dimerized CFHR2 binds tissue-bound complement fragments with avidity and efficiently competes with the physiological inhibitor CFH.
CFHR2 is involved in complement regulation. Its dimerized forms bind tissue-bound complement fragments with avidity and efficiently compete with the physiological complement inhibitor CFH. It can also associate with lipoproteins and may play a role in lipid metabolism.
CFHR2 is also called FHR2, HFL3 and CFHL2. Earlier HGNC names were H factor (complement)-like 3 and complement factor H-related 2. UniProt lists the protein as complement factor H-related protein 2. NCBI notes that alternatively spliced transcript variants exist for the gene.
NCBI Gene reports that mutations in CFHR genes, the family to which CFHR2 belongs, have been associated with dense deposit disease and atypical haemolytic-uraemic syndrome. The CFHR genes cluster with the complement factor H gene on chromosome 1 and regulate complement.
Other members of the complement factor H-related gene cluster and complement regulators with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P36980; product specifications from Assay Genie datasheets.