SYN2
SYN2 (synapsin II, also known as SYNII, SYNIIa and SYNIIb) is a neuronal phosphoprotein that coats synaptic vesicles and binds to the cytoskeleton. It is believed to regulate neurotransmitter release and belongs to the synapsin family. Browse Assay Genie's current range of SYN2 research reagents below, or read on for the biology behind the target.
SYN2 is a neuron-specific phosphoprotein that coats synaptic vesicles and binds to the cytoskeleton. It associates with the cytoplasmic surface of synaptic vesicles and selectively binds small synaptic vesicles in the presynaptic nerve terminal. It is believed to function in the regulation of neurotransmitter release, and it may also play a role in noradrenaline secretion by sympathetic neurons. Its localisation at the synapse makes the SYN2 protein a useful focus for studies of presynaptic biology.
The SYN2 gene is a member of the synapsin gene family, whose members encode neuronal phosphoproteins and share common protein domains. Synapsins are implicated in synaptogenesis and in the modulation of neurotransmitter release. Alternative splicing of the SYN2 gene produces multiple transcript variants, and the gene is also known by the names SYNII, SYNIIa and SYNIIb. The tissue inhibitor of metalloproteinase 4 gene lies within an intron of SYN2 and is transcribed in the opposite direction.
Because of its role in neurotransmitter release, the synapsin family has been linked to several neuropsychiatric diseases. Polymorphisms in SYN2 are associated with abnormal presynaptic function and related neuronal disorders, including autism, epilepsy, bipolar disorder and schizophrenia. Researchers studying synaptic vesicle organisation, presynaptic function or the genetics of these conditions often examine SYN2 alongside other synapsins such as SYN1.
SYN2 selectively binds small synaptic vesicles in the presynaptic nerve terminal, so it is studied in work on how vesicles are organised and regulated.
SYN2 is believed to regulate neurotransmitter release, and the synapsins are implicated in modulating release at the synapse.
SYN2 polymorphisms are associated with autism, epilepsy, bipolar disorder and schizophrenia, making the gene relevant to studies of neuronal disorders.
Synapsin family members are implicated in synaptogenesis, so SYN2 is relevant to research on how synapses form.
SYN2 is a neuronal phosphoprotein that coats synaptic vesicles and binds to the cytoskeleton. It is believed to regulate neurotransmitter release and may play a role in noradrenaline secretion by sympathetic neurons. It selectively binds small synaptic vesicles in the presynaptic nerve terminal.
SYN2 is also called synapsin II, Synapsin-2, SYNII, SYNIIa and SYNIIb. Alternative splicing of the gene results in multiple transcript variants. It is one member of the synapsin gene family, which also includes SYN1.
Polymorphisms in SYN2 are associated with abnormal presynaptic function and neuronal disorders, including autism, epilepsy, bipolar disorder and schizophrenia. Mouse and rat both have a Syn2 ortholog. Check the datasheet of any product for its validated reactivity.
Other synapsin family members and synaptic proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q92777; product specifications from Assay Genie datasheets.