ITPKC
ITPKC (inositol-trisphosphate 3-kinase C, also known as IP3KC or IP3-3KC) is a member of the inositol phosphokinase family. It phosphorylates inositol 1,4,5-trisphosphate and takes part in the regulation of calcium homeostasis. Browse Assay Genie's current range of ITPKC research reagents below, or read on for the biology behind the target.
ITPKC is a kinase that catalyses the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) to 1D-myo-inositol 1,3,4,5-tetrakisphosphate. Through this reaction it participates in the regulation of calcium homeostasis. InsP3 is a signalling molecule, and converting it to a tetrakisphosphate product is one route by which the enzyme influences calcium-related signalling. The enzyme can also phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate.
The human ITPKC gene encodes a member of the inositol 1,4,5-trisphosphate 3-kinase family, which belongs to the wider inositol phosphokinase (IPK) family. The encoded protein is found in the nucleus and the cytoplasm, and it has both nuclear import and nuclear export activity. This suggests that it moves between compartments rather than being fixed in one location. Orthologous genes are named Itpkc in both mouse and rat, so the target can be studied in rodent systems as well as in human material.
The enzyme is catalogued under several names. These include inositol-trisphosphate 3-kinase C, inositol 1,4,5-trisphosphate 3-kinase C, IP3KC and IP3-3KC. The HGNC places it in the inositol-trisphosphate 3-kinase family. Single nucleotide polymorphisms in the ITPKC gene are associated with Kawasaki disease, which has made the gene a point of interest for researchers studying calcium signalling in the context of this condition. Any work on the ITPKC protein should consider both its enzymatic role and its dynamic nuclear and cytoplasmic distribution.
ITPKC phosphorylates InsP3 and participates in the regulation of calcium homeostasis, making it relevant to studies of inositol phosphate signalling.
Single nucleotide polymorphisms in ITPKC are associated with Kawasaki disease, so the gene is used in studies of disease-linked variation.
The enzyme converts InsP3 to 1,3,4,5-tetrakisphosphate and can also act on inositol 2,4,5-triphosphate, informing work on inositol kinase activity.
ITPKC has both nuclear import and export activity and localises to the nucleus and cytoplasm, which suits studies of enzyme trafficking.
ITPKC catalyses the phosphorylation of inositol 1,4,5-trisphosphate (InsP3) to inositol 1,3,4,5-tetrakisphosphate and participates in the regulation of calcium homeostasis. It can also phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate. It is classed as EC 2.7.1.127.
ITPKC is also called IP3KC and IP3-3KC. Its full name is inositol-trisphosphate 3-kinase C, and an earlier name was inositol 1,4,5-trisphosphate 3-kinase C. It belongs to the inositol-trisphosphate 3-kinase family within the inositol phosphokinase family.
Single nucleotide polymorphisms in the ITPKC gene are associated with Kawasaki disease. Mouse and rat both have an orthologous gene, Itpkc. Check the datasheet of any product for its validated reactivity before using it with a given species.
Other inositol kinases, InsP3 receptors and calcium signalling targets that sit alongside ITPKC in inositol phosphate research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96DU7; product specifications from Assay Genie datasheets.