SHBG
SHBG (sex hormone binding globulin, also known as ABP and TEBG) is a secreted steroid binding protein that transports androgens and oestrogens in the blood. By controlling how much steroid circulates, it helps regulate hormone clearance and steroid responses. Browse Assay Genie's current range of SHBG research reagents below, or read on for the biology behind the target.
SHBG functions as an androgen transport protein, and it may also be involved in receptor mediated processes. It binds steroids as a dimer, and each dimer carries one molecule of steroid. Binding is specific for 5-alpha-dihydrotestosterone, testosterone and 17-beta-estradiol. By controlling the plasma concentration of these hormones, SHBG regulates their plasma metabolic clearance rate.
The SHBG gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver. It is now thought to participate in the regulation of steroid responses as well as in transport. The dimer is formed from identical or nearly identical monomers. The mature SHBG protein is secreted, and alternative splicing of the gene produces multiple transcript variants. The mouse and rat orthologs are both named Shbg.
The protein has also been known as ABP (androgen-binding protein) and TEBG (testosterone-oestrogen binding globulin). These names reflect its affinity for sex steroids. Polymorphisms in the gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus, which makes SHBG a frequent subject in endocrine and metabolic research. Researchers studying circulating steroid availability often measure SHBG alongside the hormones it carries, using tools such as an SHBG antibody or an SHBG ELISA kit.
SHBG carries androgens and oestrogens in the blood and controls their plasma concentration, so it is central to studies of circulating steroid availability.
SHBG regulates the plasma metabolic clearance rate of steroid hormones, making it relevant to work on hormone turnover.
Polymorphisms in the SHBG gene have been associated with polycystic ovary syndrome, supporting genetic and biomarker studies.
Gene polymorphisms have also been linked to type 2 diabetes mellitus, placing SHBG in metabolic disease research.
SHBG is a secreted plasma protein that transports androgens and oestrogens. Each dimer binds one steroid molecule, with specificity for 5-alpha-dihydrotestosterone, testosterone and 17-beta-estradiol. By controlling plasma steroid concentration, it regulates the metabolic clearance rate of these hormones. It may also take part in receptor mediated processes.
SHBG stands for sex hormone binding globulin. Aliases and earlier symbols include ABP, TEBG, MGC126834 and MGC138391. The gene undergoes alternative splicing, which gives rise to multiple transcript variants, so literature may describe more than one form of the transcript.
Mouse and rat both carry an ortholog named Shbg. In humans, polymorphisms in the gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Check the datasheet of any product for its validated reactivity.
Other steroid hormone, endocrine and metabolic targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P04278; product specifications from Assay Genie datasheets.