SERPINB13
SERPINB13 (serpin family B member 13, also known as HUR7 or PI13) is a member of the serpin family of serine protease inhibitors. It inhibits cathepsin K and may contribute to the control of keratinocyte proliferation or differentiation. Browse Assay Genie's current range of SERPINB13 research reagents below, or read on for the biology behind the target.
SERPINB13 is a serpin, a member of the serine protease inhibitor family, and belongs to the ov-serpin subfamily. According to the NCBI Gene summary, the encoded protein inhibits the activity of cathepsin K. UniProt annotates a possible role in the proliferation or differentiation of keratinocytes, although this function is described as tentative. The protein is found in the cytoplasm.
The SERPINB13 gene is classed by HGNC in the serpin peptidase inhibitor group. The encoded Serpin B13 protein is regulated at the transcriptional level: the gene is repressed by RUNX1. This links SERPINB13 to a transcription factor pathway that controls its expression, and it is a point of interest when studying how protease inhibitor levels are set in epithelial and tumour cells.
SERPINB13 has been known under several names, including HUR7 and PI13, and under the older descriptive names serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 13 and serpin peptidase inhibitor, clade B (ovalbumin), member 13. These reflect the ovalbumin-like clade B grouping of the family. The NCBI Gene summary reports that SERPINB13 is downregulated in many types of cancer, which has made it a subject of interest in cancer biology. A mouse ortholog, Serpinb13, is recorded for comparative work.
SERPINB13 inhibits cathepsin K, making it a useful subject for studying how serpins regulate cysteine protease activity.
UniProt notes a possible role for SERPINB13 in keratinocyte proliferation or differentiation, relevant to epidermal biology.
SERPINB13 is downregulated in many types of cancer, so its expression is studied as a feature of tumour biology.
SERPINB13 is transcriptionally repressed by RUNX1, offering a route into studying RUNX1-dependent gene control.
SERPINB13 is a serpin that inhibits the activity of cathepsin K, according to the NCBI Gene summary. UniProt also notes that it may play a role in the proliferation or differentiation of keratinocytes. The protein is located in the cytoplasm.
SERPINB13 is also called HUR7 and PI13, and UniProt lists it as Serpin B13. Earlier names include serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 13, and serpin peptidase inhibitor, clade B (ovalbumin), member 13.
The NCBI Gene summary states that SERPINB13 is downregulated in many types of cancer and is transcriptionally repressed by RUNX1. A mouse ortholog, Serpinb13, exists, so rodent models can be considered; check the datasheet of any product for its validated reactivity.
Other clade B serpins and ov-serpin family members with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UIV8; product specifications from Assay Genie datasheets.