ADH1A
ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide, also known as ADH1) is a zinc-containing alcohol dehydrogenase that oxidises primary and secondary alcohols. It encodes the alpha subunit of class I alcohol dehydrogenase. Browse Assay Genie's current range of ADH1A research reagents below, or read on for the biology behind the target.
ADH1A is an alcohol dehydrogenase that oxidises primary as well as secondary alcohols. Alcohol dehydrogenases catalyse the oxidation of alcohols to aldehydes. Ethanol is described as a very poor substrate for this particular enzyme, which distinguishes its activity from what the general name of the family might suggest. The protein is found in the cytoplasm and belongs to the zinc-containing alcohol dehydrogenase family.
The ADH1A gene encodes the alpha subunit of class I alcohol dehydrogenase. Class I enzyme is made up of several homodimers and heterodimers of alpha, beta and gamma subunits, so ADH1A is best understood alongside the other class I subunit genes. The gene is active in the liver in early foetal life but only weakly active in adult liver, a developmental pattern that matters when choosing tissues or stages for study. HGNC places it in the alcohol dehydrogenases gene group.
The ADH1A gene lies in a cluster with six additional alcohol dehydrogenase genes on the long arm of chromosome 4, including those encoding the beta and gamma subunits. ADH1 is a previous symbol for the gene. According to the NCBI Gene summary, mutations in this gene may contribute to variation in certain personality traits and substance dependence, which makes it of interest in genetic and alcohol-metabolism research.
ADH1A catalyses the oxidation of primary and secondary alcohols to aldehydes, making it a relevant enzyme for studying alcohol metabolism.
The gene is active in foetal liver but only weakly active in adult liver, offering a model for stage-specific hepatic expression.
ADH1A is the alpha subunit that forms homo- and heterodimers with beta and gamma subunits of class I alcohol dehydrogenase.
Mutations in ADH1A may contribute to variation in certain personality traits and substance dependence, supporting genetic association research.
ADH1A is an alcohol dehydrogenase that oxidises primary and secondary alcohols, converting alcohols to aldehydes. Ethanol is a very poor substrate for this enzyme. It is the alpha subunit of class I alcohol dehydrogenase and is located in the cytoplasm.
ADH1 is a previous symbol for the gene now named ADH1A by HGNC, whose full name is alcohol dehydrogenase 1A (class I), alpha polypeptide. It encodes the alpha subunit, which combines with beta and gamma subunits to form class I alcohol dehydrogenase dimers.
The NCBI Gene summary states that mutations in ADH1A may contribute to variation in certain personality traits and substance dependence. The gene sits in a cluster of seven alcohol dehydrogenase genes on chromosome 4 and is active in foetal liver but only weakly in adult liver.
Other alcohol dehydrogenase family members, including the class I beta and gamma subunits encoded in the same gene cluster.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P07327; product specifications from Assay Genie datasheets.