MT-ND6
MT-ND6 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6, also known as NAD6, ND6 and MTND6) is a core subunit of mitochondrial respiratory chain Complex I. It helps catalyse electron transfer from NADH to ubiquinone and is needed for Complex I assembly. Browse Assay Genie's current range of MT-ND6 research reagents below, or read on for the biology behind the target.
MT-ND6 is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase, also called Complex I. Complex I catalyses electron transfer from NADH through the respiratory chain, using ubiquinone as the electron acceptor. The MT-ND6 protein is essential for both the catalytic activity and the assembly of Complex I, and it enables NADH dehydrogenase (ubiquinone) activity. It is involved in mitochondrial electron transport from NADH to ubiquinone and in mitochondrial respiratory chain Complex I assembly.
The MT-ND6 gene is encoded in the mitochondrial genome rather than the nuclear genome. It belongs to the HGNC groups for NADH:ubiquinone oxidoreductase core subunits and mitochondrially encoded protein coding genes. The protein, annotated by UniProt as NADH-ubiquinone oxidoreductase chain 6, belongs to the Complex I subunit 6 family and is located in the mitochondrial inner membrane. Researchers studying this subunit may use the symbols NAD6, ND6 or MTND6, or the earlier names NADH dehydrogenase 6 and mitochondrially encoded NADH dehydrogenase 6. Orthologs are named Mtnd6 in mouse and Mt-nd6 in rat.
MT-ND6 has been implicated in Leber hereditary optic neuropathy, Leigh disease and spinal muscular atrophy with lower extremity predominant 2B. This makes the subunit a frequent subject in studies of Complex I function, mitochondrial genetics and the biology of mitochondrial disease.
MT-ND6 is a core subunit required for Complex I catalytic activity, making it relevant to studies of NADH to ubiquinone electron transfer.
The protein is essential for Complex I assembly, so it is studied in work on how the respiratory chain complex is built.
MT-ND6 is implicated in Leber hereditary optic neuropathy and Leigh disease, which are central to mitochondrial disorder research.
As a mitochondrially encoded gene, MT-ND6 is used in studies of the mitochondrial genome and its protein-coding genes.
MT-ND6 is a core subunit of Complex I, the mitochondrial membrane NADH dehydrogenase. Complex I catalyses electron transfer from NADH through the respiratory chain, with ubiquinone as the electron acceptor. MT-ND6 is essential for the catalytic activity and assembly of Complex I.
The gene is also written NAD6, ND6 or MTND6. Earlier names include NADH dehydrogenase 6 and mitochondrially encoded NADH dehydrogenase 6. UniProt lists the protein as NADH-ubiquinone oxidoreductase chain 6, a member of the Complex I subunit 6 family.
MT-ND6 is implicated in Leber hereditary optic neuropathy, Leigh disease and spinal muscular atrophy with lower extremity predominant 2B. Orthologs exist in mouse (Mtnd6) and rat (Mt-nd6); check the datasheet of any product for its validated reactivity.
Other mitochondrially encoded Complex I subunits and respiratory chain components with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P03923; product specifications from Assay Genie datasheets.