FGF5
FGF5 (fibroblast growth factor 5) is a secreted, heparin-binding member of the fibroblast growth factor family. It regulates cell proliferation and differentiation and is best known as a negative regulator of hair growth, where it drives the transition from anagen into catagen. Browse Assay Genie's current range of FGF5 research reagents below, or read on for the biology behind the target.
FGF5 plays an important role in the regulation of cell proliferation and cell differentiation. It is required for normal regulation of the hair growth cycle. The protein acts as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen, the apoptosis-induced regression phase.
The FGF5 gene encodes a secreted protein that belongs to the heparin-binding growth factors family. It is a member of the fibroblast growth factor (FGF) family, whose members have broad mitogenic and cell survival activities and are involved in embryonic development, cell growth, morphogenesis, tissue repair, and tumour growth and invasion. HGNC places it in the group of receptor ligands within the fibroblast growth factor family. Alternatively spliced transcript variants encoding different isoforms have been identified.
The gene was first identified as an oncogene, conferring transforming potential when transfected into mammalian cells. Targeted disruption of the mouse homologue, Fgf5, produced abnormally long hair, which pointed to its function as an inhibitor of hair elongation. A rat ortholog, Fgf5, is also recognised. This combination of roles in cell growth control and the hair cycle makes FGF5 a useful subject for studies of follicle biology and FGF signalling.
FGF5 is required for normal regulation of the hair cycle and promotes the shift from anagen to catagen in the follicle.
The protein contributes to regulation of cell proliferation and differentiation, as expected for a member of the FGF family of mitogenic factors.
FGF5 was identified as an oncogene with transforming potential, and FGF family members are linked to tumour growth and invasion.
FGF family members take part in embryonic development, morphogenesis and tissue repair, placing FGF5 in studies of these processes.
FGF5 regulates cell proliferation and differentiation and is required for normal control of the hair growth cycle. It inhibits hair elongation by promoting the move from anagen, the growth phase, into catagen, the apoptosis-induced regression phase of the hair follicle.
The official name is fibroblast growth factor 5, and no alternative symbols are listed by HGNC. NCBI Gene reports that alternatively spliced transcript variants encode different isoforms. UniProt classes the protein within the heparin-binding growth factors family.
Mouse and rat both have an Fgf5 ortholog. Targeted disruption of the mouse gene produced abnormally long hair. The human gene was identified as an oncogene able to transform mammalian cells; check the datasheet of any product for its validated reactivity.
Other fibroblast growth factors, FGF-binding proteins and FGF receptors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P12034; product specifications from Assay Genie datasheets.