SLC1A5
SLC1A5 (solute carrier family 1 member 5, also known as ASCT2 and neutral amino acid transporter B(0)) is a sodium-dependent neutral amino acid transporter of the plasma membrane. It also acts as a cell surface receptor for RD114/type D retroviruses. Browse Assay Genie's current range of SLC1A5 research reagents below, or read on for the biology behind the target.
SLC1A5 encodes a sodium-dependent neutral amino acid transporter. As a member of the solute carrier family 1, it moves neutral amino acids across cellular membranes together with sodium. The protein belongs to the dicarboxylate/amino acid:cation symporter (DAACS) family, in which SLC1A5 forms its own subfamily. Beyond transport, SLC1A5 serves as a cell surface receptor for type D simian retroviruses, and the NCBI Gene summary describes it as a receptor for RD114/type D retrovirus, a role reported by Larriba and colleagues in 2001.
UniProt lists the protein as neutral amino acid transporter B(0), and it is also known by the aliases AAAT, ASCT2, RDRC and M7V1. It is localised to the cell membrane, including the apical cell membrane, and has also been annotated in the melanosome. Researchers studying the SLC1A5 gene or protein therefore often work on membrane transport and on virus-host interaction at the cell surface.
HGNC classifies the gene within both the solute carrier family 1 group and the minor histocompatibility antigens group. Its previous name was solute carrier family 1 (neutral amino acid transporter), member 5. Orthologues are recognised in mouse and rat, both named Slc1a5, which allows comparative work in standard rodent models. Related SLC1 family members, such as SLC1A1, SLC1A2, SLC1A3 and SLC1A6, are useful comparators when studying transporter specificity within the family.
SLC1A5 is a sodium-dependent neutral amino acid transporter, making it a focus for studies of how amino acids cross the plasma membrane.
SLC1A5 acts as a cell surface receptor for RD114/type D retroviruses, so it is relevant to research on viral receptor usage.
Localisation to the cell membrane, apical membrane and melanosome makes SLC1A5 a subject for studies of transporter trafficking and polarity.
As the sole member of its DAACS subfamily, SLC1A5 offers a reference point for comparing SLC1 family transporters.
SLC1A5 encodes a sodium-dependent neutral amino acid transporter located in the cell membrane. It also functions as a cell surface receptor for type D simian retroviruses and for RD114/type D retrovirus, according to UniProt and the NCBI Gene summary.
SLC1A5 is also called ASCT2, AAAT, RDRC and M7V1. UniProt names the protein neutral amino acid transporter B(0). The earlier HGNC name was solute carrier family 1 (neutral amino acid transporter), member 5.
Yes. Mouse and rat both have an orthologue named Slc1a5. Human SLC1A5 belongs to the DAACS family and the SLC1A5 subfamily. Check the datasheet of any product for its validated reactivity.
Other SLC1 family transporters and solute carrier proteins with research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q15758; product specifications from Assay Genie datasheets.