GLI1
GLI1 (GLI family zinc finger 1, also known as GLI) is a Kruppel-family zinc finger transcription factor that acts as a transcriptional activator. It is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. Browse Assay Genie's current range of GLI1 research reagents below, or read on for the biology behind the target.
GLI1 is a transcription factor that functions as a transcriptional activator. According to the NCBI Gene summary, it is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. Its activity and nuclear localisation are negatively regulated by p53 in an inhibitory loop, linking GLI1 to a second major regulatory pathway.
The GLI1 gene encodes a member of the Kruppel family of zinc finger proteins and belongs to the GLI C2H2-type zinc-finger protein family. HGNC places it in the C2H2-type zinc finger gene group. UniProt records the GLI1 protein in the cytoplasm, the nucleus and the cilium, which fits a factor that is regulated through its localisation. Multiple transcript variants encoding different isoforms have been described. UniProt notes that one isoform acts as a transcriptional activator but activates a different set of genes from isoform 1; for example, it activates expression of CD24, which isoform 1 does not.
The gene is also known by the symbol GLI, and earlier names were glioma-associated oncogene homolog 1 (zinc finger protein) and glioma-associated oncogene family zinc finger 1. The mouse ortholog is Gli1. Related family members include GLI2 and GLI3, and researchers studying GLI1 often also examine the GLI pathogenesis-related proteins GLIPR1 and GLIPR2. Researchers looking for a GLI1 antibody or a GLI1 ELISA kit usually work on hedgehog signalling, stem cell regulation and p53 crosstalk.
GLI1 is activated by the sonic hedgehog signal transduction cascade, making it a key readout of pathway activity.
The transcription factor regulates stem cell proliferation, so it is relevant to work on progenitor expansion and control.
p53 negatively regulates GLI1 activity and nuclear localisation in an inhibitory loop, a focus for studies of pathway cross-regulation.
Multiple transcript variants exist, and one isoform activates a different gene set, including CD24, from isoform 1.
GLI1 acts as a transcriptional activator. It is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. Its activity and nuclear localisation are negatively regulated by p53 in an inhibitory loop. It is found in the cytoplasm, nucleus and cilium.
GLI1 is also known as GLI. Earlier names were glioma-associated oncogene homolog 1 (zinc finger protein) and glioma-associated oncogene family zinc finger 1. Multiple transcript variants encode different isoforms, and one isoform activates a different set of genes, including CD24, from isoform 1.
The mouse ortholog is Gli1. GLI1 belongs to the GLI C2H2-type zinc-finger family, which also includes GLI2 and GLI3. Check the datasheet of any product for its validated reactivity before using it in a given species.
Other GLI family members and GLI pathogenesis-related proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P08151; product specifications from Assay Genie datasheets.