PCDH1
PCDH1 (protocadherin 1, also known as pc42) is a membrane protein of the non-clustered protocadherin group within the cadherin superfamily. It is found at cell-cell boundaries and may be involved in cell-cell interaction and cell adhesion. Browse Assay Genie's current range of PCDH1 research reagents below, or read on for the biology behind the target.
PCDH1 is thought to be involved in cell-cell interaction processes and in cell adhesion. According to the NCBI Gene summary, the encoded protein is a membrane protein found at cell-cell boundaries, and cells expressing it showed cell aggregation activity. UniProt records its subcellular location as the cell junction and the cell membrane.
The PCDH1 gene belongs to the protocadherin subfamily within the cadherin superfamily, and HGNC places it in the non-clustered protocadherins. The protein has an extracellular region containing seven cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Alternative splicing occurs in this gene, so researchers working with the PCDH1 protein should consider that more than one transcript may be produced.
PCDH1 has been linked to neural cell adhesion, which suggests a possible role in neuronal development. The gene was previously named protocadherin 1 (cadherin-like 1), and pc42 is a recorded alias. Because the functional annotation is still described in cautious terms, PCDH1 remains a useful subject for studies of how protocadherins contribute to adhesion at cell junctions.
PCDH1 may be involved in cell-cell interaction and adhesion, and cells expressing it showed aggregation activity.
Its involvement in neural cell adhesion suggests a possible role in neuronal development.
PCDH1 is a non-clustered protocadherin with seven extracellular cadherin-like domains, making it a reference for protocadherin architecture.
The protein is found at cell-cell boundaries and cell junctions, supporting work on membrane organisation at sites of contact.
PCDH1 may be involved in cell-cell interaction processes and in cell adhesion. It is a membrane protein found at cell-cell boundaries, and cells expressing it showed aggregation activity. Its role in neural cell adhesion suggests a possible function in neuronal development.
PCDH1 is also called protocadherin 1 or Protocadherin-1, with the alias pc42. An earlier name was protocadherin 1 (cadherin-like 1). Alternative splicing occurs in the gene, so the PCDH1 gene can give rise to more than one transcript.
PCDH1 is a member of the protocadherin subfamily of the cadherin superfamily, classed by HGNC as a non-clustered protocadherin. It has seven extracellular cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Check the datasheet of any product for its validated reactivity.
Other protocadherins and cadherin-superfamily adhesion proteins with research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q08174; product specifications from Assay Genie datasheets.