FKBP3
FKBP3 (FKBP prolyl isomerase 3, also known as FKBP25 or FKBP-25) is a nuclear peptidyl-prolyl cis-trans isomerase of the immunophilin family. It binds the immunosuppressants FK506 and rapamycin and accelerates protein folding. Browse Assay Genie's current range of FKBP3 research reagents below, or read on for the biology behind the target.
FKBP3 is a cis-trans prolyl isomerase, a peptidyl-prolyl isomerase (PPIase) that accelerates the folding of proteins. It belongs to the FKBP-type PPIase family, whose members act as receptors for the two immunosuppressants FK506 and rapamycin. These drugs inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 has a higher affinity for rapamycin than for FK506, so it may be an important target molecule for immunosuppression by rapamycin.
The FKBP3 gene encodes a member of the immunophilin protein family, which has roles in immunoregulation and in basic cellular processes involving protein folding and trafficking. UniProt records the protein in the nucleus. Besides the immunosuppressants, the encoded protein is reported to bind histone deacetylases, the transcription factor YY1, casein kinase II and nucleolin. These interactions link this immunophilin to nuclear processes as well as to drug binding.
The protein is known as FKBP25 or FKBP-25, after its approximate mass in kilodaltons. Earlier names include FK506-binding protein 3 (25kD) and FK506 binding protein 3, 25kDa. HGNC places the gene in the FKBP prolyl isomerase family, and the mouse ortholog is Fkbp3. Researchers studying FKBP3 often compare it with other FKBP family members, such as FKBP1A, FKBP4 and FKBP5, to separate shared isomerase activity from the functions specific to each protein.
FKBP3 binds FK506 and rapamycin, with higher affinity for rapamycin, making it relevant to studies of immunosuppression by these drugs.
As a peptidyl-prolyl cis-trans isomerase, FKBP3 accelerates protein folding and contributes to cellular folding and trafficking processes.
FKBP3 is reported to bind histone deacetylases, YY1, casein kinase II and nucleolin, offering a route into nuclear complexes.
FKBP3 is one of the FKBP-type PPIases, so it is useful for comparing immunophilin roles in immunoregulation and cell biology.
FKBP3 is a peptidyl-prolyl cis-trans isomerase that accelerates protein folding. It is also a receptor for the immunosuppressants FK506 and rapamycin, binding rapamycin with higher affinity. It is located in the nucleus and binds partners including histone deacetylases, YY1, casein kinase II and nucleolin.
FKBP3 is also called FKBP25 or FKBP-25. Previous names include FK506-binding protein 3 (25kD), FK506 binding protein 3, 25kDa, and FK506 binding protein 3. The HGNC full name is FKBP prolyl isomerase 3, and UniProt lists peptidyl-prolyl cis-trans isomerase FKBP3.
The mouse has an ortholog named Fkbp3. FKBP3 belongs to the FKBP-type PPIase family, which includes several related immunophilins. Check the datasheet of any product for its validated reactivity.
Other FKBP family immunophilins and peptidyl-prolyl isomerases with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q00688; product specifications from Assay Genie datasheets.