MYOM3
MYOM3 (myomesin 3, also known as FLJ35961) is a sarcomeric protein of striated muscle that localises to the M line. It may link the intermediate filament cytoskeleton to the M-disk of the myofibrils. Browse Assay Genie's current range of MYOM3 research reagents below, or read on for the biology behind the target.
MYOM3 is a structural component of the sarcomere, the contractile unit of striated muscle. UniProt annotates it as a protein that may link the intermediate filament cytoskeleton to the M-disk of the myofibrils. Its subcellular location is the M line of the sarcomere, within the myofibril in the cytoplasm.
The NCBI Gene summary describes the human MYOM3 gene with predicted functions, inferred rather than experimentally established. These include protein homodimerization activity, a role as a structural constituent of muscle, involvement in sarcomere organisation, and activity at the M band. Researchers working with the MYOM3 protein should treat these as predictions and confirm them in their own systems.
The gene is classed by HGNC within the I-set domain containing group and the myosin binding proteins. Its previous name was myomesin family, member 3, and FLJ35961 is a previous symbol. This places it alongside other myomesin family members such as MYOM1 and MYOM2, which also contribute to M-band architecture. The mouse ortholog is Myom3, which allows comparative work on M-band organisation in rodent models.
MYOM3 is predicted to be involved in sarcomere organisation, making it relevant to studies of how myofibril structure is assembled.
The protein localises to the M line and is predicted to be active in the M band of striated muscle.
MYOM3 may link the intermediate filament cytoskeleton to the M-disk of myofibrils, a question for muscle cytoarchitecture research.
As a myosin binding protein with I-set domains, MYOM3 can be studied alongside MYOM1 and MYOM2 to compare family members.
UniProt annotates MYOM3 as a protein that may link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. NCBI also lists predicted roles as a structural constituent of muscle and in sarcomere organisation, plus homodimerization activity.
MYOM3 stands for myomesin 3, and UniProt uses the name Myomesin-3. The previous symbol is FLJ35961 and the previous gene name was myomesin family, member 3. Check the datasheet of any product for its validated reactivity.
A mouse ortholog, Myom3, is recorded for the human gene, so rodent models can be used for comparative study. No rat ortholog is given in the data supplied. Check the datasheet of any product for its validated reactivity.
Other myomesin family members and M-band proteins of striated muscle with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q5VTT5; product specifications from Assay Genie datasheets.