PPP3R1
PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha) is the regulatory subunit of calcineurin, a calcium-dependent, calmodulin-stimulated protein phosphatase. It is also known as calcineurin subunit B type 1, CALNB1, CNB or CNB1. Browse Assay Genie's current range of PPP3R1 research reagents below, or read on for the biology behind the target.
PPP3R1 is the regulatory subunit of calcineurin, a calcium-dependent, calmodulin-stimulated protein phosphatase. Its defining role is to confer calcium sensitivity on the enzyme complex. The PPP3R1 protein is part of the calcineurin complex, where it works with a catalytic subunit such as PPP3CA, and it enables phosphatase binding and protein domain-specific binding.
UniProt records the protein as calcineurin subunit B type 1, a member of the calcineurin regulatory subunit family. HGNC places the PPP3R1 gene in the groups of protein phosphatase 3 regulatory subunits, EF-hand domain containing proteins and calcineurin subunits. The protein is found in the cytosol and at the cell membrane, including the sarcolemma, and NCBI Gene reports it as located in the plasma membrane. Mouse and rat both carry a Ppp3r1 ortholog.
In functional terms, PPP3R1 is involved in the calcineurin-NFAT signalling cascade and in positive regulation of transcription by RNA polymerase II. The gene has been implicated in Alzheimer's disease and dilated cardiomyopathy. Earlier nomenclature described it as protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform (calcineurin B, type I), which explains the aliases CALNB1, CNB and CNB1 found in the literature. Researchers studying PPP3R1 often work with a PPP3R1 antibody, PPP3R1 ELISA kit or recombinant PPP3R1 protein to examine calcineurin biology.
PPP3R1 is involved in the calcineurin-NFAT signalling cascade, making it a relevant subunit for studying calcium-regulated phosphatase signalling.
As the subunit that confers calcium sensitivity on calcineurin, PPP3R1 is central to work on calmodulin-stimulated phosphatase activity.
PPP3R1 has been implicated in Alzheimer's disease, supporting studies of calcineurin subunits in neurodegeneration.
PPP3R1 is implicated in dilated cardiomyopathy, and the protein is also detected at the sarcolemma of muscle cells.
PPP3R1 is the regulatory subunit of calcineurin, a calcium-dependent, calmodulin-stimulated protein phosphatase, and it confers calcium sensitivity on the complex. It is involved in the calcineurin-NFAT signalling cascade and in positive regulation of transcription by RNA polymerase II.
PPP3R1 is also called calcineurin subunit B type 1, CALNB1, CNB and CNB1. Older names describe it as protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform (calcineurin B, type I). Its HGNC identifier is HGNC:9317 and its UniProt accession is P63098.
Mouse and rat both have a Ppp3r1 ortholog. NCBI Gene reports that PPP3R1 is implicated in Alzheimer's disease and dilated cardiomyopathy. Check the datasheet of any product for its validated reactivity.
Calcineurin catalytic partners and other protein phosphatase catalytic and regulatory subunits with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P63098; product specifications from Assay Genie datasheets.