IMMP2L
IMMP2L (inner mitochondrial membrane peptidase subunit 2, also known as IMP2) is a mitochondrial inner membrane protease of the peptidase S26 family. It removes transit peptides from proteins imported into the mitochondria and is one of the proteins required for activity of the inner membrane peptidase (IMP) complex. Browse Assay Genie's current range of IMMP2L research reagents below, or read on for the biology behind the target.
IMMP2L catalyses the removal of transit peptides that are needed to target proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. In this way it processes the signal peptide sequences that direct mitochondrial proteins to their correct compartment. One of its known substrates is the nuclear-encoded protein DIABLO. According to the RefSeq summary, the encoded protein is one of the necessary components for the catalytic activity of the mitochondrial inner membrane peptidase (IMP) complex.
The IMMP2L protein resides in the mitochondria, where UniProt places it at the inner membrane. It is classed in the peptidase S26 family, IMP2 subfamily, with the enzyme designation EC 3.4.21.-. The name reflects its relationship to the yeast IMP2 protease, and the symbol IMP2 is retained as an alias. The IMMP2L gene is also associated with the alias IMMP2L-IT1, a previous symbol for an intronic non-protein-coding transcript. Two transcript variants encoding the same protein have been described for the human gene.
Because IMMP2L acts on proteins as they cross the inner mitochondrial membrane, it is a useful subject for studies of mitochondrial protein import, signal peptide processing and the maturation of intermembrane space proteins. A mouse ortholog, Immp2l, is recorded, allowing comparative work across species. Researchers studying the IMMP2L gene, its protein or its role within the IMP complex can use this page to find relevant reagents.
IMMP2L removes transit peptides from proteins directed from the matrix across the inner membrane into the inter-membrane space.
The protein processes signal peptide sequences that direct mitochondrial proteins to the mitochondria, and contributes to the catalytic activity of the IMP complex.
IMMP2L is known to process the nuclear-encoded protein DIABLO, making it relevant to studies of how this mitochondrial protein is prepared.
As a member of the peptidase S26 family, IMP2 subfamily, IMMP2L supports comparisons with the yeast IMP2 protease and other inner membrane peptidases.
IMMP2L catalyses removal of transit peptides needed to move proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. It is required for the catalytic activity of the inner mitochondrial membrane peptidase (IMP) complex and is known to process DIABLO.
The HGNC name is inner mitochondrial membrane peptidase subunit 2, and UniProt lists mitochondrial inner membrane protease subunit 2. Aliases include IMP2 and IMMP2L-IT1. Earlier names referred to an IMP2 inner mitochondrial membrane peptidase-like gene from S. cerevisiae. Two variants encode the same protein.
A mouse ortholog, Immp2l, is recorded, and the human protein belongs to the peptidase S26 family, IMP2 subfamily, named after the yeast IMP2 protease. For a rat ortholog no information is given here. Check the datasheet of any product for its validated reactivity.
Mitochondrial proteases, the IMP complex and other proteins involved in mitochondrial protein processing with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96T52; product specifications from Assay Genie datasheets.