CHD2
CHD2 (chromodomain helicase DNA binding protein 2) is a nuclear, ATP-dependent chromatin-remodelling factor of the SNF2/RAD54 helicase family. It binds the promoters of target genes and remodels chromatin, and the gene has also been catalogued under the aliases FLJ38614 and DKFZp547I1315. Browse Assay Genie's current range of CHD2 research reagents below, or read on for the biology behind the target.
CHD2 is an ATP-dependent chromatin-remodelling factor that binds specifically to the promoter of target genes. This binding leads to chromatin remodelling, possibly by promoting the deposition of histone H3.3. In this way the CHD2 protein is thought to influence how accessible a gene's promoter is to the transcriptional machinery.
A defined role has been described in myogenesis. CHD2 interacts with MYOD1, binds myogenic gene regulatory sequences and mediates incorporation of histone H3.3 before the onset of myogenic gene expression, which promotes expression of those genes. This makes it a useful example of a remodeller acting ahead of transcription to prepare chromatin.
The CHD2 gene belongs to the CHD family, whose members are characterised by chromo (chromatin organisation modifier) domains and SNF2-related helicase/ATPase domains. CHD genes are thought to alter gene expression by modifying chromatin structure, thereby changing access of the transcriptional apparatus to its chromosomal DNA template. CHD2 is classed with the helicases and the SNF2-related family, and UniProt places it in the SNF2/RAD54 helicase family. Alternatively spliced transcript variants encoding distinct isoforms have been reported. The mouse ortholog is Chd2. HGNC also lists the gene among the microRNA protein coding host genes.
CHD2 is an ATP-dependent remodeller that binds target gene promoters and alters chromatin, making it relevant to studies of promoter accessibility.
CHD2 is proposed to promote histone H3.3 deposition, linking it to research on histone variant incorporation and chromatin state.
CHD2 interacts with MYOD1 and mediates H3.3 incorporation at myogenic regulatory sequences before myogenic gene expression begins.
CHD family proteins are thought to change access of the transcriptional apparatus to DNA, so CHD2 is studied in gene expression control.
CHD2 is an ATP-dependent chromatin-remodelling factor that binds the promoters of target genes and remodels chromatin, possibly by promoting histone H3.3 deposition. In myogenesis it interacts with MYOD1 and mediates H3.3 incorporation before myogenic gene expression starts, promoting that expression.
CHD2 stands for chromodomain helicase DNA binding protein 2; UniProt names it ATP-dependent chromatin remodeler CHD2. Aliases include FLJ38614, DKFZp547I1315, DKFZp781D1727 and DKFZp686E01200. Alternatively spliced transcript variants encoding distinct isoforms have been found for the gene.
CHD2 belongs to the SNF2/RAD54 helicase family and the CHD family, defined by chromo and SNF2-related helicase/ATPase domains. A mouse ortholog, Chd2, exists. Check the datasheet of any product for its validated reactivity.
Other CHD family chromatin remodellers and SNF2-related helicases with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O14647; product specifications from Assay Genie datasheets.