ANKRD30A
ANKRD30A (ankyrin repeat domain 30A) is a DNA-binding transcription factor encoded on chromosome 10 and also known as NY-BR-1. It is expressed in mammary epithelium and the testis, and altered expression has been linked to breast cancer progression. Browse Assay Genie's current range of ANKRD30A research reagents below, or read on for the biology behind the target.
ANKRD30A encodes a DNA-binding transcription factor. According to the NCBI Gene summary, it is uniquely expressed in mammary epithelium and the testis, a restricted pattern that makes it a distinctive tissue-specific regulator. Altered expression levels have been associated with breast cancer progression, and this is the main disease context in which the protein has been studied.
The human ANKRD30A gene is located at 10p11.21 and produces the ankyrin repeat domain-containing protein 30A, a protein of 1,397 amino acids. HGNC places it in the N-Ank proteins gene group. UniProt does not currently annotate a subcellular location or a detailed functional description for this entry, so its molecular mechanism is best taken from the transcription factor role described by RefSeq.
The protein is also known by the alias NY-BR-1. Researchers working on breast tissue biology, testis-restricted expression or transcriptional regulation may use ANKRD30A antibody or ANKRD30A ELISA kit reagents to examine expression levels, and the ANKRD30A gene and protein as markers when studying changes associated with breast cancer progression.
Altered ANKRD30A expression has been associated with breast cancer progression, making it a candidate for studies of tumour biology.
ANKRD30A is uniquely expressed in mammary epithelium, which makes it relevant to studies of tissue-specific gene expression in the breast.
Expression restricted to mammary epithelium and the testis offers a defined pattern for investigating shared regulatory features of these tissues.
As a DNA-binding transcription factor, ANKRD30A is relevant to work on how gene expression is controlled in specialised epithelial cells.
According to the NCBI Gene summary, ANKRD30A encodes a DNA-binding transcription factor. It is uniquely expressed in mammary epithelium and the testis. Altered expression levels have been associated with breast cancer progression. UniProt provides no further functional annotation for this entry.
ANKRD30A stands for ankyrin repeat domain 30A, and the protein is named ankyrin repeat domain-containing protein 30A in UniProt. The alias NY-BR-1 is also used in the literature. HGNC lists no previous names, and classifies the gene in the N-Ank proteins group.
Mouse and rat orthologs are not given in the data available for this target, so conservation cannot be stated here. Researchers working in non-human species should confirm the relevant ortholog independently and check the datasheet of any product for its validated reactivity.
Other ankyrin repeat domain proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BXX3; product specifications from Assay Genie datasheets.