MAST4
MAST4 (microtubule associated serine/threonine kinase family member 4, also known as KIAA0303) is a cytoplasmic serine/threonine protein kinase of the microtubule-associated serine/threonine kinase family. It belongs to the AGC group within the protein kinase superfamily. Browse Assay Genie's current range of MAST4 research reagents below, or read on for the biology behind the target.
MAST4 is a member of the microtubule-associated serine/threonine protein kinases. As a protein kinase, it is classified under EC 2.7.11.1 and transfers phosphate groups to serine and threonine residues on substrate proteins. According to the NCBI Gene summary, proteins in this family contain a domain that gives the kinase the ability to determine its own scaffold, which allows the family to control the effects of their kinase activities.
The MAST4 protein is assigned to the protein kinase superfamily and, more specifically, to the AGC Ser/Thr protein kinase family. HGNC places it in two gene groups: PDZ domain containing proteins and the microtubule associated serine/threonine kinase family. UniProt records its subcellular location as the cytoplasm. The human MAST4 gene lies at 5q12.3, and the mouse ortholog is Mast4.
Alternative splicing of the MAST4 gene results in multiple transcript variants that encode different isoforms, a point worth considering when selecting reagents or interpreting results. The gene has also been catalogued under the older name KIAA0303. Related family members, such as MAST3, share the family designation and kinase architecture, so researchers studying MAST4 often consider the family as a whole.
MAST4 is a serine/threonine kinase of the AGC family, making it relevant to studies of protein phosphorylation and kinase-dependent regulation.
As a member of the microtubule-associated serine/threonine kinase family, MAST4 is studied alongside related kinases to compare family-wide features.
Family members carry a domain that lets the kinase determine its own scaffold, a feature relevant to how kinase activity is controlled.
Alternative splicing produces multiple MAST4 transcript variants and isoforms, supporting work on transcript-specific expression and function.
MAST4 is a serine/threonine protein kinase (EC 2.7.11.1) of the microtubule-associated serine/threonine kinase family. According to the NCBI Gene summary, the family contains a domain that lets the kinase determine its own scaffold to control the effects of its kinase activity. It is found in the cytoplasm.
MAST4 has also been known as KIAA0303, and its full name is microtubule associated serine/threonine kinase family member 4. Alternative splicing results in multiple transcript variants that encode different isoforms, so it is worth checking which isoform a given reagent is intended to recognise.
A mouse ortholog, Mast4, is recorded for the human gene. MAST4 belongs to the AGC Ser/Thr protein kinase family within the protein kinase superfamily. For any product, check the datasheet of any product for its validated reactivity before use in a given species.
Other members of the microtubule-associated serine/threonine kinase family with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O15021; product specifications from Assay Genie datasheets.