ZFP64
ZFP64 (zinc finger protein 64, also known as ZNF338) is a nuclear C2H2-type zinc finger protein of the krueppel family. It may help regulate mesenchymal cell differentiation by transactivating NOTCH1 target genes. Browse Assay Genie's current range of ZFP64 research reagents below, or read on for the biology behind the target.
ZFP64 is a zinc finger protein that is thought to act in the nucleus as a transcription factor. UniProt annotates it as possibly being involved in the regulation of mesenchymal cell differentiation through transactivation of NOTCH1 target genes, which places it downstream of, or alongside, NOTCH1 signalling. The NCBI Gene summary, based on Alliance of Genome Resources curation, is consistent with this. It predicts that ZFP64 enables DNA-binding transcription factor activity and binding to transcription cis-regulatory regions, and it lists involvement in mesenchymal cell differentiation. These activities are described as predicted, so the direct mechanism is worth confirming experimentally in your own system.
The ZFP64 gene encodes a protein that belongs to the krueppel C2H2-type zinc finger protein family. HGNC classifies it in the gene group Zinc fingers C2H2-type. Members of this group use zinc-coordinating finger motifs to contact DNA, which fits the predicted role of ZFP64 in regulating gene expression. UniProt gives its subcellular location as the nucleus. The mouse ortholog is Zfp64, so comparative work between human and mouse systems is possible.
The nomenclature for this gene has changed over time. The approved HGNC name is ZFP64 zinc finger protein. Earlier names were zinc finger protein 338, zinc finger protein 64 homolog (mouse) and zinc finger protein 64, and the previous symbol was ZNF338. Other aliases found in the literature and in databases include FLJ10734, FLJ12628, dJ831D17.1 and dJ548G19.1. Checking all of these names helps when you search older publications or sequence records for the ZFP64 gene and protein.
ZFP64 is implicated in the regulation of mesenchymal cell differentiation, making it a candidate factor for studies of how mesenchymal fate is controlled.
ZFP64 may transactivate NOTCH1 target genes, so it is relevant to work on how NOTCH1 signalling outputs are transcriptionally regulated.
Predicted DNA-binding and cis-regulatory region binding activity make ZFP64 a subject for studies of sequence-specific transcriptional control by zinc finger proteins.
As a krueppel C2H2-type protein with a mouse ortholog, Zfp64, ZFP64 supports comparative studies of this large transcription factor family across species.
UniProt states that ZFP64 may be involved in regulating mesenchymal cell differentiation by transactivating NOTCH1 target genes. NCBI Gene predicts that it has DNA-binding transcription factor activity and binds transcription cis-regulatory regions. It is located in the nucleus. Several of these activities are predicted rather than fully characterised.
ZFP64 was formerly called ZNF338, and its previous names include zinc finger protein 338 and zinc finger protein 64 homolog (mouse). Aliases include FLJ10734, FLJ12628, dJ831D17.1 and dJ548G19.1. UniProt lists the protein as zinc finger protein 64. Searching under all of these names helps you find older records.
A mouse ortholog, Zfp64, is recorded for the human gene, and the NCBI Gene summary draws on Alliance of Genome Resources curation across model organisms. Check the datasheet of any product for its validated reactivity before using it with a particular species.
Other zinc finger proteins and the NOTCH1 signalling partner linked to ZFP64 function.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9NTW7; product specifications from Assay Genie datasheets.