CMTM7
CMTM7 (CKLF-like MARVEL transmembrane domain-containing protein 7, also known as CKLFSF7 or FLJ30992) is a membrane protein of the chemokine-like factor family. The CMTM7 gene is described as a tumour suppressor that regulates the G1/S transition of the cell cycle. Browse Assay Genie's current range of CMTM7 research reagents below, or read on for the biology behind the target.
CMTM7 is a member of the CKLF-like MARVEL transmembrane domain-containing family, which sits within the wider chemokine-like factor superfamily. According to the NCBI Gene summary, this gene acts as a tumour suppressor. It regulates the G1/S transition in the cell cycle and influences epidermal growth factor receptor (EGFR)/protein kinase B (AKT) signalling during tumour pathogenesis. These roles make CMTM7 a point of interest for researchers studying cell-cycle control and growth factor signalling in cancer.
The CMTM7 protein is annotated as a membrane protein. The CMTM7 gene is one of several chemokine-like factor genes found in a cluster on chromosome 3. Alternative splicing of the gene gives rise to multiple transcript variants that encode different isoforms. The mouse counterpart is Cmtm7, which allows comparative work across species.
The chemokine-like factor superfamily was described as a novel family, similar to both the chemokines and the transmembrane 4 superfamily. This is the origin of the earlier names for CMTM7, including chemokine-like factor super family 7 and the symbol CKLFSF7. The gene was later renamed under the CKLF like MARVEL transmembrane domain containing group. Related family members such as CMTM1, CMTM2, CMTM4, CMTM5, CMTM6 and CMTM8 share this nomenclature and are often studied alongside CMTM7.
CMTM7 is reported to act as a tumour suppressor, so it is studied in the context of tumour pathogenesis.
The gene regulates the G1/S transition in the cell cycle, linking CMTM7 to control of cell proliferation.
CMTM7 influences epidermal growth factor receptor and protein kinase B signalling during tumour development.
As part of a gene cluster on chromosome 3, CMTM7 is studied alongside other chemokine-like factor family members.
According to the NCBI Gene summary, CMTM7 acts as a tumour suppressor. It regulates the G1/S transition in the cell cycle and epidermal growth factor receptor/protein kinase B signalling during tumour pathogenesis. The protein is annotated as a membrane protein.
CMTM7 is also known as CKLFSF7 and FLJ30992. Earlier names include chemokine-like factor super family 7. Alternative splicing of the gene produces multiple transcript variants that encode different isoforms, so check which isoform a reagent targets.
CMTM7 has a mouse ortholog, Cmtm7. It belongs to the chemokine-like factor superfamily and is one of several such genes clustered on chromosome 3. Check the datasheet of any product for its validated reactivity.
Other CMTM family members from the chemokine-like factor superfamily with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96FZ5; product specifications from Assay Genie datasheets.