MAD1L1
MAD1L1 (mitotic arrest deficient 1 like 1, also known as MAD1, HsMAD1, TXBP181, PIG9 or TP53I9) is a component of the mitotic spindle assembly checkpoint. It interacts with MAD2L1 and helps prevent anaphase onset until chromosomes are properly aligned. Browse Assay Genie's current range of MAD1L1 research reagents below, or read on for the biology behind the target.
MAD1L1 is a component of the mitotic spindle assembly checkpoint (SAC), the surveillance mechanism that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The protein functions as a homodimer and interacts with MAD2L1. In hepatocellular carcinoma, UniProt annotation describes a role in which MAD1L1 sequesters MAD2L1 in the cytoplasm, preventing MAD2L1 from acting as an activator of the SAC. This results in SAC impairment and chromosomal instability.
The MAD1L1 gene encodes the protein known in UniProt as mitotic spindle assembly checkpoint protein MAD1, and it belongs to the MAD1 family. The protein is annotated at several locations: the nucleus, the kinetochore at the centromere, the nuclear envelope, the centrosome, the spindle and spindle pole, and the cytoplasm. Alternative splicing of the gene produces multiple transcript variants. The mouse ortholog is Mad1l1. HGNC places the gene in the group of microRNA protein coding host genes.
The gene has been catalogued under several names, including MAD1 (mitotic arrest deficient, yeast, homolog)-like 1, reflecting its origin as a homolog of the yeast checkpoint gene. Aliases include HsMAD1, TXBP181, MAD1, PIG9 and TP53I9. NCBI Gene notes that MAD1L1 may play a role in cell cycle control and tumour suppression, making it a frequent subject in studies of mitosis, chromosome segregation and genomic stability.
MAD1L1 is a component of the checkpoint that delays anaphase until chromosomes are aligned at the metaphase plate.
The protein may contribute to cell cycle control, making it a relevant target when examining mitotic progression.
Cytoplasmic sequestration of MAD2L1 by MAD1L1 is linked to SAC impairment and chromosomal instability in hepatocellular carcinoma.
MAD1L1 may play a role in tumour suppression, supporting its study in cancer biology and genome maintenance.
MAD1L1 is part of the mitotic spindle assembly checkpoint, which prevents anaphase until all chromosomes are aligned at the metaphase plate. It acts as a homodimer and interacts with MAD2L1. It may also contribute to cell cycle control and tumour suppression.
MAD1L1 is also called MAD1, HsMAD1, TXBP181, PIG9 and TP53I9, and UniProt names the protein mitotic spindle assembly checkpoint protein MAD1. Earlier HGNC names described it as a yeast MAD1 homolog. Alternative splicing gives multiple transcript variants.
A mouse ortholog, Mad1l1, is recorded. In hepatocellular carcinoma, MAD1L1 sequesters MAD2L1 in the cytoplasm, impairing the spindle assembly checkpoint and causing chromosomal instability. Check the datasheet of any product for its validated reactivity.
MAD2L1, the checkpoint partner of MAD1L1, and other MAD-named targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y6D9; product specifications from Assay Genie datasheets.