SLC12A4
SLC12A4, also known as KCC1 and formerly named solute carrier family 12 (potassium/chloride transporter), member 4, is a plasma membrane protein of the SLC12A transporter family. It mediates the coupled movement of potassium and chloride ions across the cell membrane. Browse Assay Genie's current range of SLC12A4 research reagents below, or read on for the biology behind the target.
SLC12A4 encodes a member of the SLC12A transporter family, placed in the K/Cl co-transporter subfamily. According to the NCBI Gene summary, the encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. As a co-transporter, it moves the two ions together rather than individually, which links the handling of potassium to that of chloride at the cell surface.
The SLC12A4 gene is expressed ubiquitously, so the protein is not confined to a single tissue type. UniProt records its subcellular location as the cell membrane, consistent with a role in transport across the plasma membrane. Multiple alternatively spliced transcript variants encoding distinct isoforms have been described for the SLC12A4 gene, which is worth bearing in mind when interpreting results from different transcripts or protein forms. Orthologues are annotated in the mouse and the rat, both under the symbol Slc12a4.
The protein is widely referred to as KCC1, and HGNC lists the previous name as solute carrier family 12 (potassium/chloride transporter), member 4. HGNC places it in the solute carrier family 12 gene group, alongside related transporters such as SLC12A1, SLC12A2, SLC12A3, SLC12A5 and SLC12A7. Researchers comparing members of this group often use the shared family membership to study how closely related transporters differ in ion handling and distribution.
SLC12A4 mediates coupled potassium and chloride movement across the plasma membrane, making it a relevant target for studies of cellular ion handling.
As part of the SLC12A family and K/Cl co-transporter subfamily, SLC12A4 is used as a reference point when comparing related cation-chloride transporters.
The ubiquitous expression of the SLC12A4 gene makes it a useful subject for examining transporter distribution across many cell and tissue contexts.
Alternatively spliced transcript variants encode distinct SLC12A4 isoforms, supporting research into how splicing shapes transporter diversity.
SLC12A4 encodes a member of the SLC12A transporter family. According to the NCBI Gene summary, the protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. UniProt assigns it to the K/Cl co-transporter subfamily and lists the cell membrane as its location.
Yes. KCC1 is an alias of SLC12A4. HGNC also records the previous name solute carrier family 12 (potassium/chloride transporter), member 4. The official symbol follows the solute carrier nomenclature, while KCC1 reflects its role as a potassium-chloride co-transporter. Both names appear in the literature.
Mouse and rat orthologues are annotated, both named Slc12a4. The human gene is expressed ubiquitously and has multiple splice variants encoding distinct isoforms. For any product, check the datasheet of any product for its validated reactivity.
Other members of the SLC12A family and further solute carrier transporters with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UP95; product specifications from Assay Genie datasheets.