There are no products listed under this category.
APOBEC4
APOBEC4 (apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4) is a putative deaminase of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases. It was previously known as C1orf169, and its physiological substrate is not yet known. Browse Assay Genie's current range of APOBEC4 research reagents below, or read on for the biology behind the target.
APOBEC4 is annotated as a putative deaminase, and UniProt notes that its physiological substrate is not yet known. It belongs to the cytidine and deoxycytidylate deaminase family. The NCBI Gene summary places it within the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases, a group of enzymes that convert cytidine to uridine.
Other members of the AID/APOBEC family are involved in mRNA editing, somatic hypermutation and recombination of immunoglobulin genes, and innate immunity to retroviral infection. These roles provide the context in which APOBEC4 is studied, although the source annotation does not assign APOBEC4 itself to any of these processes. Its enzymatic activity and targets therefore remain open questions for researchers working on this protein.
The human APOBEC4 gene is listed by HGNC in the group of apolipoprotein B mRNA editing enzyme catalytic subunits. It was formerly designated chromosome 1 open reading frame 169 (C1orf169), and has also appeared under the names MGC26594, FLJ25691 and RP1-127C7.4. Orthologues are named Apobec4 in both mouse and rat, which allows comparative work in rodent models. Subcellular location is not annotated in UniProt.
APOBEC4 is a putative cytidine deaminase with no known physiological substrate, so defining its catalytic activity is a central question.
Family members act in mRNA editing, immunoglobulin gene diversification and retroviral restriction, making APOBEC4 a point of comparison within the family.
As a member of a family that converts cytidine to uridine, APOBEC4 is relevant to research on polynucleotide modification.
Mouse and rat both carry an Apobec4 orthologue, supporting cross-species investigation of the gene and its protein.
APOBEC4 is a putative deaminase, and UniProt states that its physiological substrate is not yet known. It belongs to the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine, but its specific function has not been defined in the source annotation.
The protein is listed in UniProt as Putative deaminase APOBEC-4. Aliases and former symbols include MGC26594, FLJ25691, RP1-127C7.4 and C1orf169. The former HGNC name was chromosome 1 open reading frame 169, and the gene is in the apolipoprotein B mRNA editing enzyme catalytic subunits group.
Yes. Orthologues named Apobec4 are recorded for both mouse and rat, so the gene is present in common rodent models. Please check the datasheet of any product for its validated reactivity before planning cross-species experiments.
Other AID/APOBEC family cytidine deaminases and related enzymes involved in RNA editing and innate immunity.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8WW27; product specifications from Assay Genie datasheets.
There are no products listed under this category.