BCMA
BCMA (TNF receptor superfamily member 17, also known as TNFRSF17, CD269, BCM and TNFRSF13A) is a cell-membrane receptor for BAFF and APRIL. It promotes B-cell survival and contributes to the regulation of humoral immunity. Browse Assay Genie's current range of BCMA research reagents below, or read on for the biology behind the target.
BCMA is a receptor for the TNF superfamily ligands TNFSF13B (also called BLyS, BAFF or TALL-1) and TNFSF13 (APRIL). Ligand engagement promotes B-cell survival and contributes to the regulation of humoral immunity. Signalling through BCMA activates NF-kappa-B and JNK (MAPK8). The receptor has also been shown to bind various TRAF family members, so it may transduce signals for cell survival and proliferation.
The TNFRSF17 gene encodes a member of the tumour necrosis factor receptor superfamily. According to NCBI Gene, the receptor is preferentially expressed in mature B lymphocytes and may be important for B-cell development and autoimmune responses. UniProt records the protein at the cell membrane and in the endomembrane system. The mouse ortholog is Tnfrsf17, which allows comparative work on the BCMA protein in rodent models.
HGNC classes the gene within both the CD molecules and the tumour necrosis factor receptor superfamily, which explains the alternative designation CD269. The gene has also been listed under the symbols BCM and TNFRSF13A, and its previous HGNC name was tumour necrosis factor receptor superfamily, member 17. Researchers studying B-cell biology often use a BCMA antibody or BCMA ELISA kit to follow receptor expression and the ligand-receptor axis it shares with other BAFF and APRIL receptors.
BCMA promotes B-cell survival as a receptor for BAFF and APRIL, making it a key readout in studies of B-cell homeostasis.
The receptor plays a role in regulating humoral immunity, so it is studied in models of antibody-mediated responses.
BCMA activates NF-kappa-B and JNK, and binds TRAF family members, providing a route to dissect TNF receptor signal transduction.
Preferential expression in mature B lymphocytes and a possible role in autoimmune response make BCMA relevant to B-cell-driven disease studies.
BCMA is a receptor for BAFF (TNFSF13B) and APRIL (TNFSF13). It promotes B-cell survival and plays a role in regulating humoral immunity. Signalling through the receptor activates NF-kappa-B and JNK, and it also binds TRAF family members that may transduce survival and proliferation signals.
The HGNC symbol is TNFRSF17, and the full name is TNF receptor superfamily member 17. Aliases and previous symbols include BCM, CD269 and TNFRSF13A. The ligand BAFF is also known as BLyS or TALL-1, which can matter when searching the literature.
A mouse ortholog, Tnfrsf17, exists, supporting work in murine models; check the datasheet of any product for its validated reactivity. NCBI Gene notes that the receptor may be important for B-cell development and autoimmune response.
Other TNF receptor superfamily members, including BAFF receptor family relatives, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q02223; product specifications from Assay Genie datasheets.