MAGEA4
MAGEA4 (MAGE family member A4, also known as MAGE-41 or MAGE-X2) is a member of the MAGEA family that regulates cell proliferation and negatively regulates p53-mediated apoptosis. The protein is listed by UniProt as melanoma-associated antigen 4. Browse Assay Genie's current range of MAGEA4 research reagents below, or read on for the biology behind the target.
MAGEA4 regulates cell proliferation by inhibiting cell cycle arrest at the G1 phase. It also negatively regulates p53-mediated apoptosis. Through these two activities, the MAGEA4 protein acts on both the control of cell division and the response to p53-driven cell death.
The MAGEA4 gene belongs to the MAGEA gene family, which is clustered at chromosomal location Xq28. According to the NCBI Gene summary, family members encode proteins with 50 to 80% sequence identity to each other. Their promoters and first exons vary considerably. This suggests that the family allows the same function to be expressed under different transcriptional controls. Several variants of the MAGEA4 gene have been found, and all encode the same protein.
The MAGEA genes have been implicated in some hereditary disorders, such as dyskeratosis congenita. HGNC places MAGEA4 in the MAGE family and records the previous name melanoma antigen family A4. Aliases include MAGE4A, MAGE4B, MAGE-41, MAGE-X2, MGC21336, CT1.4 and MAGE4. Related family members such as MAGEA1, MAGEA2, MAGEA3, MAGEA8 and MAGEA10 are often studied alongside it when researchers compare MAGEA family functions.
MAGEA4 inhibits cell cycle arrest at the G1 phase, making it relevant to studies of how proliferation is regulated.
MAGEA4 negatively regulates p53-mediated apoptosis, so it is a focus for work on how cell death pathways are restrained.
Family members share 50 to 80% sequence identity but differ in promoters, supporting studies of transcriptional control of related genes.
MAGEA genes have been implicated in some hereditary disorders, including dyskeratosis congenita, a link explored in genetic research.
MAGEA4 regulates cell proliferation by inhibiting cell cycle arrest at the G1 phase. It also negatively regulates p53-mediated apoptosis. These annotations place it in pathways that control cell division and cell death. Check the datasheet of any product for its validated reactivity.
MAGEA4 is also called MAGE4A, MAGE4B, MAGE-41, MAGE-X2, MGC21336, CT1.4 and MAGE4. HGNC lists the previous name melanoma antigen family A4, and UniProt names the protein melanoma-associated antigen 4. Several gene variants encode the same protein.
MAGEA4 is one of a cluster of MAGEA genes at Xq28. Family proteins share 50 to 80% sequence identity, but their promoters and first exons vary considerably, which suggests the same function can be expressed under different transcriptional controls.
Other MAGEA family members that share sequence identity with MAGEA4 and are studied alongside it.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P43358; product specifications from Assay Genie datasheets.