PRDX3
PRDX3 (peroxiredoxin 3) is a mitochondrial, thiol-specific peroxidase that reduces hydrogen peroxide and organic hydroperoxides and protects cells from oxidative stress. It is also known as MER5, AOP-1, AOP1, SP-22 and antioxidant protein 1. Browse Assay Genie's current range of PRDX3 research reagents below, or read on for the biology behind the target.
PRDX3 is a thiol-specific peroxidase that catalyses the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. By detoxifying peroxides it plays a role in cell protection against oxidative stress. UniProt also reports that PRDX3 acts synergistically with MAP3K13 to regulate activation of NF-kappa-B in the cytosol, and that it is required for the maintenance of physical strength. The enzyme is annotated as a thioredoxin-dependent peroxide reductase.
The PRDX3 gene encodes a mitochondrial protein with antioxidant function, and the protein is found mainly in the mitochondrion, with additional annotation to the cytoplasm and early endosome. It belongs to the peroxiredoxin family, AhpC/Prx1 subfamily, and is part of the HGNC peroxiredoxins gene group alongside PRDX1, PRDX2, PRDX4, PRDX5 and PRDX6. Alternative splicing of the gene results in multiple transcript variants, and related pseudogenes have been identified on chromosomes 1, 3, 13 and 22.
PRDX3 is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli lacking that subunit. This origin explains the earlier name antioxidant protein 1 (AOP-1). The human and mouse genes are highly conserved and lie in syntenic regions. Sequence comparisons suggest the peroxiredoxins form a family involved in regulating cellular proliferation, differentiation and antioxidant functions. PRDX3 can protect cells from oxidative stress and, according to NCBI, can promote cell survival in prostate cancer.
PRDX3 detoxifies hydrogen peroxide and organic hydroperoxides, making it a central protein for studying cellular protection against oxidative stress.
As a mitochondrial thioredoxin-dependent peroxide reductase, PRDX3 is relevant to studies of peroxide handling within the mitochondrion.
PRDX3 acts synergistically with MAP3K13 to regulate NF-kappa-B activation in the cytosol, linking peroxidase biology to signalling.
NCBI Gene reports that PRDX3 can promote cell survival in prostate cancer, supporting its study in tumour biology.
PRDX3 is a thiol-specific peroxidase that reduces hydrogen peroxide and organic hydroperoxides to water and alcohols. This protects cells from oxidative stress. It also acts with MAP3K13 to regulate NF-kappa-B activation in the cytosol and is required for maintenance of physical strength.
PRDX3 is also called MER5, AOP-1, AOP1 and SP-22, and its previous name was antioxidant protein 1. UniProt lists it as thioredoxin-dependent peroxide reductase, mitochondrial. Alternative splicing of the gene produces multiple transcript variants.
Yes. The human and mouse genes are highly conserved and map to syntenic regions, and mouse and rat both have a Prdx3 ortholog. PRDX3 is also similar to a Salmonella alkylhydroperoxide reductase subunit. Check the datasheet of any product for its validated reactivity.
Other peroxiredoxin family members and antioxidant enzymes studied alongside PRDX3 in redox and oxidative stress research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P30048; product specifications from Assay Genie datasheets.