ADNP
ADNP (activity dependent neuroprotector homeobox, also known as KIAA0784 or ADNP1) is a nuclear protein with one homeobox and nine zinc finger domains, suggesting it acts as a transcription factor. It is upregulated by vasoactive intestinal peptide and linked to neural differentiation and WNT signalling. Browse Assay Genie's current range of ADNP research reagents below, or read on for the biology behind the target.
ADNP is thought to be involved in transcriptional regulation. The encoded protein contains one homeobox and nine zinc finger domains, a architecture that suggests it functions as a transcription factor. UniProt places it in the nucleus and associated with chromosomes. It positively modulates WNT-beta-catenin signalling, acting by regulating phosphorylation of CTNNB1 (beta-catenin) and thereby stabilising it.
Vasoactive intestinal peptide (VIP) is a neuroprotective factor that stimulates the growth of some tumour cells and inhibits others. The ADNP gene is upregulated by VIP, and the ADNP protein may mediate some VIP-associated effects on normal growth and cancer proliferation. The gene is also upregulated in normal proliferative tissues, and the protein may increase the viability of certain cell types through modulation of p53 activity.
Beyond these roles, ADNP may be required for neural induction and neuronal differentiation, and may be involved in erythroid differentiation. Alternatively spliced transcript variants have been described that encode the same protein. The gene is classed by HGNC among the C2H2-type zinc fingers and the ZF class homeoboxes, and its previous name was activity-dependent neuroprotector. Mouse and rat each carry an Adnp ortholog.
ADNP carries a homeobox and nine zinc finger domains and is thought to regulate transcription, making it a subject for studies of nuclear and chromatin-associated factors.
ADNP positively modulates WNT-beta-catenin signalling by regulating CTNNB1 phosphorylation and stability, a link relevant to pathway regulation research.
ADNP may be required for neural induction and neuronal differentiation, and is associated with VIP-linked neuroprotective effects.
ADNP is upregulated by VIP and may contribute to its stimulatory effect on certain tumour cells, possibly through modulation of p53 activity.
ADNP is thought to act as a transcription factor. It positively modulates WNT-beta-catenin signalling by regulating phosphorylation of CTNNB1, stabilising it. It may also be required for neural induction and neuronal differentiation, and may be involved in erythroid differentiation.
The HGNC name is activity dependent neuroprotector homeobox, and the UniProt name is activity-dependent neuroprotector homeobox protein. Aliases include KIAA0784 and ADNP1. The previous gene name was activity-dependent neuroprotector. Alternatively spliced transcripts have been described that encode the same protein.
ADNP is upregulated by vasoactive intestinal peptide (VIP), a neuroprotective factor that stimulates growth of some tumour cells and inhibits others. ADNP may mediate part of VIP's stimulatory effect. Mouse and rat Adnp orthologs exist; check the datasheet of any product for its validated reactivity.
Related WNT signalling components, p53 and VIP pathway targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9H2P0; product specifications from Assay Genie datasheets.