RYBP
RYBP (RING1 and YY1 binding protein, also known as YEAF1, AAP1 and DEDAF) is a component of a Polycomb group PRC1-like complex that helps maintain transcriptional repression during development. It also regulates the ubiquitin-mediated turnover of proteins such as TP53. Browse Assay Genie's current range of RYBP research reagents below, or read on for the biology behind the target.
RYBP is a component of a Polycomb group (PcG) multiprotein PRC1-like complex. This class of complex is required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PRC1-like complexes act through chromatin remodelling and histone modification, mediating monoubiquitination of histone H2A at Lys-119 and so leaving chromatin heritably changed in its expressibility. RYBP may stimulate this H2A ubiquitination by recruiting the complex to target sites. A PRC1-like complex containing RYBP also mediates H2A Lys-119 monoubiquitination on the X chromosome and is required for normal silencing of one X chromosome in XX females.
Beyond chromatin, RYBP inhibits the ubiquitination and subsequent degradation of TP53, and so plays a role in regulating transcription of TP53 target genes. It may also regulate the ubiquitin-mediated proteasomal degradation of other proteins, such as FANK1, to regulate apoptosis. It may act as a repressor of the transcriptional activity of E4TF1, and it may bind DNA. In breast cancer, RYBP may help repress tumour growth and metastasis by down-regulating SRRM3. NCBI Gene annotation also links the protein to negative regulation of proteasomal ubiquitin-dependent protein catabolism, positive regulation of DNA-templated transcription and positive regulation of apoptosis.
The RYBP gene belongs to the HGNC group of RANBP2-type zinc fingers. The protein is found in the nucleus, including the nucleoplasm, and in the cytoplasm. The mouse ortholog is Rybp. The aliases YEAF1, AAP1 and DEDAF are used in the literature alongside the approved symbol.
RYBP is part of a PRC1-like complex that mediates histone H2A Lys-119 monoubiquitination to maintain repression of genes including Hox genes.
A PRC1-like complex containing RYBP is required for normal silencing of one X chromosome in XX females.
RYBP inhibits ubiquitination and degradation of TP53, influencing transcription of TP53 target genes and proteasomal protein turnover.
RYBP may regulate apoptosis through proteins such as FANK1 and may repress breast cancer growth and metastasis by down-regulating SRRM3.
RYBP is a component of a Polycomb PRC1-like complex that mediates monoubiquitination of histone H2A Lys-119 and maintains gene repression during development. It may recruit the complex to target sites. It also inhibits ubiquitination and degradation of TP53, thereby affecting transcription of TP53 target genes.
RYBP stands for RING1 and YY1 binding protein. Aliases and previous symbols include YEAF1, AAP1 and DEDAF. The UniProt entry names the protein RING1 and YY1-binding protein. The mouse ortholog is written Rybp, and the HGNC places the gene in the RANBP2-type zinc finger group.
UniProt notes that RYBP may regulate apoptosis by controlling ubiquitin-mediated degradation of proteins such as FANK1. It may also help repress tumour growth and metastasis in breast cancer by down-regulating SRRM3, and it influences TP53 target gene transcription by protecting TP53 from degradation.
Polycomb complex partners, TP53 pathway proteins and apoptosis-related targets connected to RYBP biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8N488; product specifications from Assay Genie datasheets.