ROMO1
ROMO1 (reactive oxygen species modulator 1) is a small mitochondrial inner membrane protein that increases the level of reactive oxygen species (ROS) in cells. It also has antibacterial activity, and is known by the aliases MTGMP, bA353C18.2 and C20orf52. Browse Assay Genie's current range of ROMO1 research reagents below, or read on for the biology behind the target.
ROMO1 is a mitochondrial membrane protein that is responsible for increasing the level of reactive oxygen species (ROS) in cells. This makes it a point of interest wherever mitochondrial ROS production is under study. In addition to this role, the ROMO1 protein has antimicrobial activity against a variety of bacteria, including S. aureus, P. aeruginosa and M. tuberculosis. It acts by inducing bacterial membrane breakage.
The ROMO1 gene encodes a short protein that localises to the mitochondrion inner membrane. UniProt places it in the MGR2 family, while HGNC classifies the gene within the Tim17 family. The gene is located on chromosome 20, and a mouse ortholog, Romo1, is recorded in the data.
The official name, reactive oxygen species modulator 1, reflects its effect on cellular ROS levels. The gene was previously designated chromosome 20 open reading frame 52 (C20orf52), and other aliases include MTGMP and bA353C18.2. Researchers may encounter any of these names in older literature and database records.
ROMO1 increases the level of reactive oxygen species in cells, making it relevant to studies of mitochondrial ROS generation.
As an inner membrane protein assigned to the Tim17 and MGR2 families, ROMO1 is a subject for mitochondrial membrane research.
ROMO1 shows antibacterial activity by inducing bacterial membrane breakage, supporting work on antimicrobial protein mechanisms.
Activity against S. aureus, P. aeruginosa and M. tuberculosis links ROMO1 to studies of protein-mediated defence against bacterial pathogens.
ROMO1 is a mitochondrial membrane protein that increases the level of reactive oxygen species in cells. It also has antibacterial activity against a variety of bacteria, including S. aureus, P. aeruginosa and M. tuberculosis, which it achieves by inducing bacterial membrane breakage.
ROMO1 stands for reactive oxygen species modulator 1. Aliases and previous symbols include MTGMP, bA353C18.2 and C20orf52, the last reflecting the earlier name chromosome 20 open reading frame 52. Searching under any of these may be useful when reviewing older records.
A mouse ortholog, Romo1, is recorded for the human gene. UniProt assigns the protein to the MGR2 family, and HGNC lists the gene in the Tim17 family. Check the datasheet of any product for its validated reactivity.
Other mitochondrial membrane proteins, Tim17 family members and ROS-related targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P60602; product specifications from Assay Genie datasheets.